1School of Materials Science and Engineering, North Minzu University, Yinchuan 750021, P.R. China.
2State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, Beijing 100083, China.
Acta Bioeng Biomech. 2024 Feb 10;25(4):93-101. doi: 10.37190/abb-02338-2023-03. Print 2023 Dec 1.
Stress shielding and the need for secondary surgery are the two major challenges faced by permanent metallic implants, and the emerging Ca-Mg-Zn calcium-based bulk amorphous alloys, with Young's modulus comparable to that of human bone, good biocompatibility, and in vivo degradation, are highly promising materials for bioimplants. Few studies have been reported on the glass formation ability (GFA) and corrosion degradation behavior of Ca-Mg-Zn amorphous alloys in the human body. In this work, we discuss a study on Ca MgZn ( = 0, 2, 4, 6, 8, 10) alloys, focusing on changes in Zn content near eutectic points and their impact on microstructure and biological corrosion behavior. A copper mold spray casting method has been developed to prepare amorphous bar alloys and amorphous crystalline composite bar alloys with a diameter of 3 mm, which has been verified by X-ray diffraction, electrochemical treatment, and immersion tests. The experimental results demonstrated that the CaZn and CaZn phases were precipitated in the 3 mm bar material Ca MgZn ( = 0, 2, 4), and Ca MgZn ( = 6, 8, 10) was completely amorphous. The CaMgZn alloy showed the best glass-forming ability, while the CaMgZn alloy exhibited superior corrosion resistance. Cytotoxicity experiments showed that Ca-Mg-Zn alloys have good biocompatibility and can be used as biomedical materials.
应力屏蔽和需要二次手术是永久性金属植入物面临的两大挑战，新兴的 Ca-Mg-Zn 钙基块状非晶合金，其杨氏模量与人骨相当，具有良好的生物相容性和体内降解性，是生物植入物的极具前景的材料。关于 Ca-Mg-Zn 非晶合金在人体中的玻璃形成能力（GFA）和腐蚀降解行为的研究很少。在这项工作中，我们讨论了 CaMgZn（=0、2、4、6、8、10）合金的研究，重点研究了共晶点附近 Zn 含量的变化及其对微观结构和生物腐蚀行为的影响。采用铜模喷射铸造法制备直径为 3mm 的非晶棒合金和非晶-晶复合棒合金，通过 X 射线衍射、电化学处理和浸泡试验进行了验证。实验结果表明，在 3mm 棒材 CaMgZn（=0、2、4）中析出了 CaZn 和 CaZn 相，而 CaMgZn（=6、8、10）完全是非晶态的。CaMgZn 合金具有最佳的玻璃形成能力，而 CaMgZn 合金则表现出优异的耐腐蚀性。细胞毒性实验表明，Ca-Mg-Zn 合金具有良好的生物相容性，可作为生物医学材料。
