Department of Epidemiology-Data-Biostatistics, Delegation of Clinical Research and Innovation (DRCI), Foch Hospital, Suresnes, France.
J Clin Hypertens (Greenwich). 2023 Aug;25(8):757-767. doi: 10.1111/jch.14669. Epub 2023 Jul 5.
Few investigations have been performed between tobacco smoking, alcohol, and arterial stiffness. The purpose of our study was to investigate the association between smoking use and alcohol with arterial stiffness index (ASI) in a middle-age population. Smoking pack-years and cigarettes per day were defined as alcohol consumption in units/day. Sex associations between smoking and alcohol with ASI were estimated using multiple linear regressions. Interactions and synergistic effects were investigating. 98 039 individuals of the UK Biobank cohort were included (45 457 men and 52 582 women). ASI levels were higher in men than in women (9.91 vs. 8.71 m/s, p < .001), and showed higher relationship to smoking tobacco in multiple linear regression models in women than in men (FDR logworth 78.4 vs. 52.7). The findings revealed that ASI was higher among current smokers than never smokers in both sex and after adjustment for all covariates (in men 10.4 vs. 9.6 and in women 9.5 vs. 8.5 m/s, p < .001). Alcohol consumption per day was positively associated with higher levels of ASI in both sex, but with a less relationship (FDR logworth for men = 2.8, for women = 2.5). An interaction was observed between smoking information and alcohol in men but not in women. Synergistic effects were observed by adding smoking information on alcohol consumption models in men and women (p = .029, p < .001, respectively). Smoking and alcohol were associated with higher ASI in both sex but with a higher relationship among women. The findings suggest the importance of considering smoking and alcohol consumption cessation in cardiovascular diseases prevention.
很少有研究调查吸烟、饮酒和动脉僵硬之间的关系。我们的研究目的是调查中年人群中吸烟和饮酒与动脉僵硬度指数（ASI）之间的关系。吸烟包年数和每天吸烟支数定义为每天饮酒单位数。使用多元线性回归估计吸烟和饮酒与 ASI 之间的性别相关性。还调查了相互作用和协同效应。纳入了英国生物银行队列的 98039 名个体（45457 名男性和 52582 名女性）。男性的 ASI 水平高于女性（9.91 与 8.71m/s，p<0.001），并且在女性中，多元线性回归模型显示吸烟与 ASI 的关系高于男性（FDR logworth 78.4 与 52.7）。研究结果表明，在两性中，与从不吸烟者相比，当前吸烟者的 ASI 更高，且在调整所有协变量后仍然如此（男性中为 10.4 与 9.6，女性中为 9.5 与 8.5m/s，p<0.001）。在两性中，每天饮酒与更高水平的 ASI 呈正相关，但相关性较低（男性的 FDR logworth=2.8，女性的 FDR logworth=2.5）。在男性中观察到吸烟信息与酒精之间存在相互作用，但在女性中没有。在男性和女性中，在饮酒模型中添加吸烟信息观察到协同效应（p=0.029，p<0.001）。吸烟和饮酒与两性的 ASI 升高相关，但在女性中相关性更高。这些发现表明，在预防心血管疾病时，考虑戒烟和戒酒非常重要。
