Shiga J, Mori W
Acta Pathol Jpn. 1985 Jul;35(4):849-61. doi: 10.1111/j.1440-1827.1985.tb00627.x.
The lung was chosen as a target organ of the univisceral Shwartzman reaction in this study. Rabbits were selected as the experimental animal, and E. coli endotoxin was used as the Shwartzman reagent. Preparative procedures were applied through the trachea into the lung in several ways; direct injection of the endotoxin solution and inhalation of the atomized endotoxin solution by natural breathing. The provocation was made by intravenous injection of the same endotoxin 24 hours later. The lung showed severe hemorrhage associated with inflammatory cell infiltration, interstitial fibrosis, macrophage accumulation, etc. The severity and extent of these changes varied, to some extent, between groups as well as between individual animals. The fundamental character was, however, common to all, and the incidence of the lesion in the lung was quite high. The relationship of the present results to idiopathic pulmonary hemorrhage and Goodpasture's syndrome is also discussed from the viewpoint of human pathology.
在本研究中，肺被选为单脏器施瓦茨曼反应的靶器官。选用兔子作为实验动物，并使用大肠杆菌内毒素作为施瓦茨曼试剂。通过气管以多种方式将制剂注入肺内；直接注射内毒素溶液以及通过自然呼吸吸入雾化的内毒素溶液。24小时后通过静脉注射相同的内毒素进行激发。肺表现出严重出血，并伴有炎症细胞浸润、间质纤维化、巨噬细胞聚集等。这些变化的严重程度和范围在不同组之间以及不同个体动物之间在一定程度上有所不同。然而，其基本特征对所有情况而言都是相同的，并且肺中病变的发生率相当高。还从人体病理学的角度讨论了本研究结果与特发性肺出血和古德帕斯彻综合征的关系。
