Ohno Y, Shiga J, Mori W
Department of Pathology, Faculty of Medicine, University of Tokyo, Japan.
Virchows Arch A Pathol Anat Histopathol. 1989;416(1):75-80. doi: 10.1007/BF01606472.
In this study, a new experimental model for hepatic necrosis is presented using rabbits, and E. coli endotoxin as the Shwartzman reagent. A segment of the liver was chosen as a target site for the univisceral Shwartzman reaction. Endotoxin-Lipiodol emulsion was used as a preparative injection via the portal venous branch into the target segment by direct puncture. Provocation was made by an intravenous injection of endotoxin 24 h later. A marked and sharply demarcated necrotic area was produced selectively in the target segment; specific changes were not seen in other lobes of the liver or other parts of the body. This model, strongly enhanced by using Lipiodol, seems to be a subtype of the univisceral Shwartzman reaction of the liver.
在本研究中，提出了一种使用兔子和大肠杆菌内毒素作为施瓦茨曼试剂的肝坏死新实验模型。选择肝脏的一段作为单脏器施瓦茨曼反应的靶部位。通过直接穿刺经门静脉分支将内毒素-碘油乳剂作为预注射剂注入靶段。24小时后静脉注射内毒素进行激发。在靶段选择性地产生了一个明显且界限清晰的坏死区域；在肝脏的其他叶或身体的其他部位未观察到特异性变化。通过使用碘油显著增强的该模型似乎是肝脏单脏器施瓦茨曼反应的一种亚型。
