Mori W, Shiga J, Kato A
Virchows Arch A Pathol Anat Histol. 1979 May 31;382(2):179-89. doi: 10.1007/BF01102873.
Acute, severe, and extensive necrosis of the liver was produced in pregnant and non-pregnant female adult rabbits by the Shwartzman mechanism. Shwartzman reagent (E. coli endotoxin) was administered in various combinations by three routes of injection, the portal vein (mesenteric vein), the bile duct, and the ear vein. Morphologic changes of the extrahepatic organs were minimal. The similarity to massive necrosis in human liver and the effect of pregnancy on hepatic necrosis in rabbit and man were discussed. The lesion is presented as a new animal model for acute massive hepatic necrosis and is proposed as a third category of Shwartzman reaction, designated the univisceral type.
通过施瓦茨曼机制在怀孕和未怀孕的成年雌性兔子中引发了肝脏的急性、严重和广泛性坏死。通过门静脉（肠系膜静脉）、胆管和耳静脉这三种注射途径以不同组合给予施瓦茨曼试剂（大肠杆菌内毒素）。肝外器官的形态学变化极小。讨论了其与人类肝脏大片坏死的相似性以及妊娠对兔子和人类肝脏坏死的影响。该病变被呈现为一种急性大片肝坏死的新动物模型，并被提议作为施瓦茨曼反应的第三类，命名为单脏器型。
