绝经后早期女性骨质疏松症预防性治疗期间血清骨钙素及其他骨转换生化指标的评估
Serum bone Gla protein and other biochemical estimates of bone turnover in early postmenopausal women during prophylactic treatment for osteoporosis.
作者信息
Pødenphant J, Christiansen C, Catherwood B D, Deftos L J
出版信息
Acta Med Scand. 1985;218(3):329-33. doi: 10.1111/j.0954-6820.1985.tb06133.x.
Serum bone Gla protein (BGP) and conventional biochemical indices of bone metabolism were determined in 66 early postmenopausal women during a double-blind therapeutic trial performed to investigate the effect of oestrogen, calcium and 1,25 (OH)2D3 on postmenopausal osteoporosis. The biochemical variables were determined before, during and after withdrawal of therapy. We found a very high correlation between serum BGP and serum alkaline phosphatase--a measure of bone formation, less high correlation between serum BGP and the remaining parameters--indices of bone resorption. It is concluded that serum BGP probably reflects bone formation and may prove to be a useful new biochemical marker.
在一项双盲治疗试验中，对66名绝经后早期女性测定了血清骨钙素（BGP）和传统的骨代谢生化指标，该试验旨在研究雌激素、钙和1,25（OH）2D3对绝经后骨质疏松症的影响。在治疗前、治疗期间和停药后测定生化变量。我们发现血清BGP与血清碱性磷酸酶（一种骨形成指标）之间存在非常高的相关性，血清BGP与其余参数（骨吸收指标）之间的相关性较低。结论是血清BGP可能反映骨形成，可能被证明是一种有用的新生化标志物。
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