Department of Experimental Physiology and Pathophysiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Pawińskiego 3c, Warsaw, 02-106, Poland.
Department of Bioeconomy, Institute of Natural Fibres & Medicinal Plants-National Research Institute, Wojska Polskiego 71b, Poznań, 60-630, Poland.
Macromol Biosci. 2024 Oct;24(10):e2400145. doi: 10.1002/mabi.202400145. Epub 2024 Jul 29.
Despite the significant progress in wound healing, chronic skin wounds remain a challenge for today's medicine. Due to the growing popularity of natural materials, silk protein-based dressings are gaining more attention in this field. Most studies refer to silk fibroin because sericin has been considered a waste product for years. However, sericin is also worth noting. Sericin-based dressings are mainly studied in cell cultures or animals. Sericin is the dressings' main component or can be included in more complex, advanced biomaterials. Recent studies highlight sericin's important role, noting its biocompatibility, biodegradability, and beneficial effects in skin wound healing, such as antibacterial activity, antioxidant and anti-inflammatory effects, or angiogenic properties. Developing sericin-based biomaterials is often simple, free of toxic by-products, and inexpensive, requiring no highly sophisticated apparatus. As a result, sericin-based dressings can be widely used in wound healing and have low environmental impact. However, the literature in this area is further limited. The following review collects and describes recent studies showing silk sericin's influence on skin wound healing.
尽管在伤口愈合方面取得了重大进展，但慢性皮肤伤口仍然是当今医学面临的挑战。由于天然材料越来越受欢迎，基于丝蛋白的敷料在该领域受到了更多关注。大多数研究都提到了丝素纤维，因为丝胶多年来一直被认为是一种废物。然而，丝胶也值得注意。基于丝胶的敷料主要在细胞培养物或动物中进行研究。丝胶是敷料的主要成分，或者可以包含在更复杂、更先进的生物材料中。最近的研究强调了丝胶的重要作用，指出其生物相容性、可生物降解性以及在皮肤伤口愈合中的有益作用，如抗菌活性、抗氧化和抗炎作用或血管生成特性。开发基于丝胶的生物材料通常很简单，没有有毒副产品，而且价格低廉，不需要非常复杂的仪器。因此，基于丝胶的敷料可以广泛应用于伤口愈合，并且对环境的影响较小。然而，该领域的文献进一步受到限制。本综述收集并描述了最近的研究，这些研究表明丝胶对皮肤伤口愈合的影响。
