Hu Doudou, Li Tiandong, Liang Wen'an, Wang Yeyuan, Feng Min, Sun Jingchen
Subtropical Sericulture and Mulberry Resources Protection and Safety Engineering Research Center, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong 510642, China.
Subtropical Sericulture and Mulberry Resources Protection and Safety Engineering Research Center, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong 510642, China.
J Control Release. 2023 Jan;353:303-316. doi: 10.1016/j.jconrel.2022.11.019. Epub 2022 Dec 6.
Silk sericin is a class of protein biopolymers produced by silkworms. Increasing attention has been paid to silk sericin for biomedical applications in the last decade, not only because of its excellent biocompatibility and biodegradability but also due to the pharmacological activities stemming from its unique amino acid compositions. In this review, the biological properties of silk sericin, including curing specific diseases and promoting tissue regeneration, as well as underlying mechanisms are summarized. We consider the antioxidant activity of silk sericin as a fundamental property, which could account for partial biological activities, despite the exact mechanisms of silk sericin's effect remaining unknown. Based on the reactive groups on silk sericin, approaches of bottom-up fabrication of silk sericin-based biomaterials are highlighted, including non-covalent interactions and chemical reactions (reduction, crosslinking, bioconjugation, and polymerization). We then briefly present the cutting-edge advances of silk sericin-based biomaterials applied in tissue engineering and drug delivery. The challenges of silk sericin-based biomaterials are proposed. With more bioactivities and underlying mechanisms of silk sericin uncovered, it is going to boost the therapeutic potential of silk sericin-based biomaterials.
丝胶是蚕产生的一类蛋白质生物聚合物。在过去十年中，丝胶因其在生物医学应用方面的潜力而受到越来越多的关注，这不仅是因为其具有出色的生物相容性和生物降解性，还因其独特的氨基酸组成所产生的药理活性。在这篇综述中，总结了丝胶的生物学特性，包括治疗特定疾病和促进组织再生以及潜在机制。我们认为丝胶的抗氧化活性是其基本特性，尽管丝胶作用的确切机制尚不清楚，但这可以解释其部分生物学活性。基于丝胶上的反应基团，重点介绍了基于丝胶的生物材料的自下而上制造方法，包括非共价相互作用和化学反应（还原、交联、生物共轭和聚合）。然后简要介绍了基于丝胶的生物材料在组织工程和药物递送方面的前沿进展。提出了基于丝胶的生物材料面临的挑战。随着更多丝胶的生物活性和潜在机制被揭示，这将提升基于丝胶的生物材料的治疗潜力。
