Paladini Federica, D'Urso Fabiana, Panico Angelica, Lanzillotti Carmen, Broccolo Francesco, Pollini Mauro
Department of Experimental Medicine, University of Salento, Via Monteroni, 73100 Lecce, Italy.
Caresilk S.r.l.s., Via Monteroni c/o Technological District DHITECH, 73100 Lecce, Italy.
Biomimetics (Basel). 2025 Jun 11;10(6):387. doi: 10.3390/biomimetics10060387.
Sericin, a natural glycoprotein constituting 20-30% of the silk cocoon, has emerged as a promising biomaterial due to its excellent biological properties, including biocompatibility, antioxidant properties and potential applications in regenerative medicine. The quality and the features of sericin are strongly dependent on the extraction and purification methods, which can employ mild conditions to preserve the molecular integrity of the protein or recovery techniques from waste streams produced during the industrial degumming processes. The silk industry prioritizes fiber yield over protein preservation, so often harsh alkaline conditions at high temperatures are adopted. These divergent approaches result in fundamentally different products with distinct molecular characteristics and functional capabilities. This review comprehensively examines the current technological approaches for sericin extraction techniques and for its recovery from textile industry waste, focusing on how these aspects affect the biological properties of the protein and the potential applications.
丝胶是一种天然糖蛋白，占蚕茧的20%-30%，由于其优异的生物学特性，包括生物相容性、抗氧化特性以及在再生医学中的潜在应用，已成为一种很有前景的生物材料。丝胶的质量和特性在很大程度上取决于提取和纯化方法，这些方法可以采用温和的条件来保持蛋白质的分子完整性，或者采用从工业脱胶过程中产生的废物流中回收的技术。丝绸行业优先考虑纤维产量而非蛋白质保存，因此常常采用高温下的强碱条件。这些不同的方法导致了具有截然不同分子特征和功能能力的产品。本综述全面研究了目前丝胶提取技术及其从纺织工业废料中回收的技术方法，重点关注这些方面如何影响蛋白质的生物学特性和潜在应用。
