• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

解锁心理-社会-皮肤轴:一项双盲随机安慰剂对照研究揭示了一种新型局部制剂对皮肤质量、吸引力、生活质量和性满意度的影响。

Unlocking the psycho-social-dermal axis: A double blinded randomized placebo controlled study unveiling the influence of a novel topical formulation on skin quality, attractiveness, quality of life, and sexual satisfaction.

机构信息

Cosmetic Laser Dermatology, San Diego, California, USA.

Department of Medicine, McGill University, Montreal, Quebec, Canada.

出版信息

J Cosmet Dermatol. 2024 Sep;23(9):2905-2917. doi: 10.1111/jocd.16496. Epub 2024 Jul 29.

DOI:10.1111/jocd.16496
PMID:39073288
Abstract

BACKGROUND

Improved skin appearance is closely linked to higher self-esteem, favorable first impressions, and enhanced quality of life, with skincare products often being formulated with biostimulatory and regenerative ingredients to both enhance skin health and provide psychological benefits. Certain components, such as phospholipids and botanicals, may not only improve skin quality, but also impact mood, romantic bonding, and sexual attraction.

AIMS

To assess whether a novel topical skin care product formulated with a proprietary combination of proteins, lipids, and botanical derivatives, can potentially result in a robust psycho-social-dermatological benefit via modulation epidermal oxytocin and pheromonal pathways.

PATIENTS/METHODS: In this single-center prospective, randomized, controlled, double-blinded study, 40 female subjects were randomly assigned to use of either active novel skincare products, or placebos, for 4-8 weeks. Skin assessments, standardized photography, first impression ratings, and questionnaires on confidence and sexual satisfaction were conducted.

RESULTS

Thirty-nine subjects completed the study and demonstrated a statistically significant improvement in skin quality following 4 and 8 weeks of use, with improvements of greater magnitude demonstrated with a longer duration of use. Product users projected a better first impression and appeared on average 3 years younger than their actual age, with 86% of subjects reporting increased confidence. Product users found random people of the opposite sex to be more attractive 88% of the time and reported improvement in sexual satisfaction in 90% of the categories.

CONCLUSIONS

The use of this novel topical product culminated in statistically significant improvements in skin quality, confidence, sexual relationship satisfaction, perceived attractiveness, and youthfulness, highlighting its potential in anti-aging and mood enhancement.

摘要

背景

皮肤外观的改善与自尊心的提高、良好的第一印象和更高的生活质量密切相关,护肤品通常采用生物刺激和再生成分来增强皮肤健康并提供心理益处。某些成分,如磷脂和植物提取物,不仅可以改善皮肤质量,还可以影响情绪、浪漫关系和性吸引力。

目的

评估一种新型的局部皮肤护理产品,该产品采用专利蛋白质、脂质和植物衍生混合物配方,是否可以通过调节表皮催产素和信息素途径,对心理社会皮肤产生有益的影响。

患者/方法:在这项单中心前瞻性、随机、对照、双盲研究中,将 40 名女性患者随机分配使用活性新型护肤品或安慰剂,持续 4-8 周。进行皮肤评估、标准化摄影、第一印象评分以及关于自信和性满意度的问卷。

结果

39 名患者完成了研究,在使用 4 周和 8 周后皮肤质量有显著改善,使用时间越长,改善程度越大。产品使用者对自己的第一印象评价更好,平均看起来比实际年龄年轻 3 岁,86%的患者报告自信心增强。88%的时间里,产品使用者认为随机遇到的异性更有吸引力,90%的患者报告在性满意度的各个方面都有所提高。

结论

使用这种新型局部产品可显著改善皮肤质量、自信、性关系满意度、感知吸引力和年轻度,突出了其在抗衰老和情绪提升方面的潜力。

相似文献

1
Unlocking the psycho-social-dermal axis: A double blinded randomized placebo controlled study unveiling the influence of a novel topical formulation on skin quality, attractiveness, quality of life, and sexual satisfaction.解锁心理-社会-皮肤轴:一项双盲随机安慰剂对照研究揭示了一种新型局部制剂对皮肤质量、吸引力、生活质量和性满意度的影响。
J Cosmet Dermatol. 2024 Sep;23(9):2905-2917. doi: 10.1111/jocd.16496. Epub 2024 Jul 29.
2
Topical skin therapies in subjects undergoing full facial rejuvenation.在进行全面面部年轻化的患者中使用局部皮肤疗法。
J Cosmet Dermatol. 2019 Jun;18(3):798-805. doi: 10.1111/jocd.12977. Epub 2019 Apr 29.
3
Multi-Center, Double-Blind, Vehicle-Controlled Clinical Trial of an Alpha and Beta Defensin-Containing Anti-Aging Skin Care Regimen With Clinical, Histopathologic, Immunohistochemical, Photographic, and Ultrasound Evaluation.含α和β防御素的抗衰老护肤方案的多中心、双盲、赋形剂对照临床试验,包括临床、组织病理学、免疫组织化学、摄影及超声评估
J Drugs Dermatol. 2018 Apr 1;17(4):426-441.
4
Anti-aging proof of concept study: results and summary.抗衰老概念验证研究:结果与总结
J Drugs Dermatol. 2014 Sep;13(9):1074-81.
5
Clinical Benefits of Circadian-based Antioxidant Protection and Repair.基于昼夜节律的抗氧化保护与修复的临床益处。
J Drugs Dermatol. 2020 Dec 1;19(12):1209-1214. doi: 10.36849/JDD.2020.5355.
6
A Randomized Study to Assess the Efficacy of Skin Rejuvenation Therapy in Combination With Neurotoxin and Full Facial Filler Treatments.一项评估皮肤年轻化疗法联合肉毒素和全脸填充治疗效果的随机研究。
J Drugs Dermatol. 2018 Jan 1;17(1):48-54.
7
Evaluation of a novel anti-aging topical formulation containing cycloastragenol, growth factors, peptides, and antioxidants.一种含有环黄芪醇、生长因子、肽和抗氧化剂的新型抗衰老外用制剂的评估。
J Drugs Dermatol. 2014 Sep;13(9):1135-9.
8
Clinical Efficacy of a Novel Two-Part Skincare System on Pollution-Induced Skin Damage.一种新型两步护肤系统对污染引起的皮肤损伤的临床疗效
J Drugs Dermatol. 2018 Sep 1;17(9):975-981.
9
Combining topical dermal infused exosomes with injected calcium hydroxylapatite for enhanced tissue biostimulation.将局部真皮注入的外泌体与注射用羟基磷灰石相结合以增强组织生物刺激作用。
J Cosmet Dermatol. 2023 Mar;22 Suppl 1:15-27. doi: 10.1111/jocd.15695.
10
Assessment of the safety and efficacy of topical copper chlorophyllin in women with photodamaged facial skin.外用叶绿素铜钠盐对光损伤面部皮肤女性安全性和有效性的评估。
J Drugs Dermatol. 2015 Apr;14(4):401-4.

引用本文的文献

1
Skinspan: A Holistic Roadmap for Extending Skin Longevity With Evidence-Based Interventions.皮肤跨度:通过循证干预延长皮肤寿命的整体路线图。
J Cosmet Dermatol. 2025 Sep;24(9):e70432. doi: 10.1111/jocd.70432.