Draelos Zoe Diana, Makino Elizabeth T, Kadoya Kuniko, Nguyen Audrey, Jiang Lily I, Mehta Rahul C
J Drugs Dermatol. 2020 Dec 1;19(12):1209-1214. doi: 10.36849/JDD.2020.5355.
Skin activities follow endogenous circadian rhythms resulting in differences between daytime and nighttime properties. To address the variations in skin needs, a novel circadian-based dual serum system (LVS) was developed. A 12-week, double-blind, randomized, regimen-controlled, multi-center study was conducted to assess the efficacy and tolerability of LVS on subjects presenting with moderate-severe photodamage. 61 Female subjects (36–65 years; Fitzpatrick skin types I–VI) completed the study. The active group received LVS (daytime serum and nighttime serum) and basic skin care regimen (moisturizer and SPF 35 sunscreen), while the control group received the basic skin care regimen only. In addition to clinical grading, subject self-assessment questionnaires, and standardized photography, punch biopsies were taken in a subset of subjects for immunohistochemistry. Additionally, swab samples were taken for skin surface oxidation analysis. Significant improvements over control were observed in the active group in Radiance (weeks 4, 8, and 12), Overall Photodamage, Tactile Toughness, and Global Fine Lines/Wrinkles (week 12). Biopsy results, skin swab analysis and standardized photographs support the clinical grading findings. At all follow-up visits, LVS was consistently highly rated over control by subjects, with a significant proportion of subjects agreeing at week 12 that LVS “improved the radiance of my skin,” and “improved the overall health and look of my skin”. Results from this study suggest that LVS may provide essential protective and reparative effects to skin exposed to the damaging effects of environmental factors, and also demonstrates the value of including skin circadian rhythm-based concepts in a topical skincare regimen. J Drugs Dermatol. 2020;19(12): doi:10.36849/JDD.2020.5355.
皮肤活动遵循内源性昼夜节律，导致白天和夜间的皮肤特性存在差异。为满足皮肤需求的变化，研发了一种新型的基于昼夜节律的双血清系统（LVS）。开展了一项为期12周的双盲、随机、方案对照、多中心研究，以评估LVS对中重度光损伤受试者的疗效和耐受性。61名女性受试者（36 - 65岁；Fitzpatrick皮肤分型I - VI）完成了该研究。活性组接受LVS（日间血清和夜间血清）及基础皮肤护理方案（保湿霜和防晒系数为35的防晒霜），而对照组仅接受基础皮肤护理方案。除了临床分级、受试者自我评估问卷和标准化摄影外，还对部分受试者进行了打孔活检以进行免疫组织化学检测。此外，还采集了拭子样本进行皮肤表面氧化分析。活性组在光泽度（第4、8和12周）、总体光损伤、触感粗糙度和整体细纹/皱纹（第12周）方面相对于对照组有显著改善。活检结果、皮肤拭子分析和标准化照片支持临床分级结果。在所有随访中，受试者对LVS的评价始终高于对照组，相当一部分受试者在第12周时认同LVS“改善了我的皮肤光泽”以及“改善了我的皮肤整体健康状况和外观”。本研究结果表明，LVS可能为暴露于环境因素损伤作用下的皮肤提供重要的保护和修复作用，同时也证明了在局部护肤方案中纳入基于皮肤昼夜节律概念的价值。《药物皮肤病学杂志》。2020年；19(12)：doi:10.36849/JDD.2020.5355 。
