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通过磷脂酰胆碱/胆固醇纳米脂质体经皮递送肉毒杆菌毒素-A 治疗痤疮后瘢痕。

Transdermal delivery of botulinum toxin-A through phosphatidylcholine/cholesterol nanoliposomes for treatment of post-acne scarring.

机构信息

Department of Medical Cosmetology, The First Clinical Medical College of China Three Gorges University, Yichang Central People's Hospital, Institute of Medical Cosmetology, China Three Gorges University, Yichang, China.

College of Biological & Pharmaceutical Sciences, China Three Gorges University, Yichang, China.

出版信息

J Mater Sci Mater Med. 2024 Jul 29;35(1):41. doi: 10.1007/s10856-024-06810-1.

DOI:10.1007/s10856-024-06810-1
PMID:39073502
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11286643/
Abstract

As an acne sequela, post-acne scarring (PSA) has huge negative impact on sufferers' quality of life because of aesthetical embarrassment. Transdermal delivery of botulinum toxin-A (BTXA) is a promising strategy for PAS treatment, but currently reported approaches are far from satisfactory. In this work, phosphatidylcholine/cholesterol (PC/Chol) nanoliposomes were utilized for encapsulation and transdermal delivery of BTXA. The composition, structure, morphology, size, size distribution, etc. of as-prepared BTXA@liposome nanoparticles were investigated in detail. Simulated transdermal delivery assay indicated that the diffusion depth of the BXTA@liposome nanoparticles was nearly 8 times that of pure BTXA and reached 380 μm. 12 facial PSA patients were recruited to evaluate the curative effect of the BTXA@liposome nanoparticles on PSA. Through ECCA (échelle d'évaluation clinique des cicatrices d'acné) scoring and self-evaluation of patients, the resultant data indicated that compared to hyaluronic acid (HA) hydrogel treatment the BTXA@liposome/HA hydrogel treatment could better relieve PSA to some extent but didn't show significant advantage. Further work is needed to verify the feasibility and curative effect of this method in PSA treatment in the future.

摘要

作为痤疮后遗症，痤疮后瘢痕（PSA）会因美观问题给患者的生活质量带来巨大负面影响。将肉毒毒素-A（BTXA）经皮给药是治疗 PAS 的一种很有前途的策略，但目前报道的方法远不能令人满意。在这项工作中，我们利用磷脂酰胆碱/胆固醇（PC/Chol）纳米脂质体包封和经皮递送 BTXA。详细研究了所制备的 BTXA@liposome 纳米颗粒的组成、结构、形态、大小、大小分布等。模拟经皮传递试验表明，BTXA@liposome 纳米颗粒的扩散深度接近纯 BTXA 的 8 倍，达到 380μm。招募了 12 名面部 PSA 患者来评估 BTXA@liposome 纳米颗粒对 PSA 的治疗效果。通过 ECCA（痤疮瘢痕评估量表）评分和患者自评，结果数据表明，与透明质酸（HA）水凝胶治疗相比，BTXA@liposome/HA 水凝胶治疗在一定程度上能更好地缓解 PSA，但没有显示出明显的优势。未来需要进一步的工作来验证这种方法在 PSA 治疗中的可行性和疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/183f/11286643/c7762f878d56/10856_2024_6810_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/183f/11286643/c2aed6e2a24c/10856_2024_6810_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/183f/11286643/d29d7e6462ea/10856_2024_6810_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/183f/11286643/59bfaec5fa73/10856_2024_6810_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/183f/11286643/eae288f72c6d/10856_2024_6810_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/183f/11286643/c7762f878d56/10856_2024_6810_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/183f/11286643/c2aed6e2a24c/10856_2024_6810_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/183f/11286643/d29d7e6462ea/10856_2024_6810_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/183f/11286643/59bfaec5fa73/10856_2024_6810_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/183f/11286643/eae288f72c6d/10856_2024_6810_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/183f/11286643/c7762f878d56/10856_2024_6810_Fig5_HTML.jpg

相似文献

[1]
Transdermal delivery of botulinum toxin-A through phosphatidylcholine/cholesterol nanoliposomes for treatment of post-acne scarring.

J Mater Sci Mater Med. 2024-7-29

[2]
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[3]
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[5]
[Long-term effect of botulinum toxin type A injection on hypertrophic acne scar].

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[6]
ECCA grading scale: an original validated acne scar grading scale for clinical practice in dermatology.

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[7]
Effectiveness of microneedle fractional radiofrequency combined with transcutaneous delivery of botulinum toxin in the management of post-acne scars.

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[8]
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J Eur Acad Dermatol Venereol. 2020-12

[9]
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Lasers Med Sci. 2023-9-19

[10]
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引用本文的文献

[1]
Intelligent transdermal nanoparticles as synergizing advanced delivery systems for precision therapeutics.

Mater Today Bio. 2025-8-22

[2]
Sialic Acid-Loaded Nanoliposomes with Enhanced Stability and Transdermal Delivery for Synergistic Anti-Aging, Skin Brightening, and Barrier Repair.

Pharmaceutics. 2025-7-24

本文引用的文献

[1]
Recent Advances in Oral and Transdermal Protein Delivery Systems.

Angew Chem Int Ed Engl. 2023-3-1

[2]
Microneedling combined with botulinum toxin-A versus microneedling combined with platelet-rich plasma in treatment of atrophic acne scars: a comparative split face study.

Arch Dermatol Res. 2023-5

[3]
Successful Topical Application of Botulinum Toxin After Microneedling Versus Microneedling Alone for the Treatment of Atrophic Post Acne Scars: A Prospective, Split-face, Controlled Study.

J Clin Aesthet Dermatol. 2022-7

[4]
The effects of intermolecular interactions on the stability and in vitro drug release of daunorubicin/cytarabine co-loaded liposome.

Colloids Surf B Biointerfaces. 2022-9

[5]
Transdermal Delivery of Antigenic Protein Using Ionic Liquid-Based Nanocarriers for Tumor Immunotherapy.

ACS Appl Bio Mater. 2022-6-20

[6]
The effectiveness of botulinum toxin type A (BTX-A) in the treatment of facial skin oily seborrhea, enlarged pores, and symptom complex of post-acne.

Int J Dermatol. 2021-10

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J Pharm Innov. 2022

[8]
Piperacillin Encapsulation in Nanoliposomes Using Modified Freeze-Drying of a Monophase Solution Method: Preparation, Characterization and In Vitro Antibacterial Activity.

Curr Microbiol. 2020-9

[9]
Development of Botulinum Toxin A-Coated Microneedles for Treating Palmar Hyperhidrosis.

Mol Pharm. 2019-10-29

[10]
Perspectives of Lipid-Based Drug Carrier Systems for Transdermal Delivery.

Crit Rev Ther Drug Carrier Syst. 2018

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