Ebrahim Howyda, Elardi Amal, Khater Sayed, Morsi Hala
All authors are with Zagazig University Hostpital in Zagazig, Egypt.
J Clin Aesthet Dermatol. 2022 Jul;15(7):26-31.
Acne scars are a source of cosmetic concern for most of the patients.
We sought to compare the clinical efficacy and safety of topical botulinum toxin A (BTX-A) application immediately after microneedling (Mn) versus Mn with saline in the treatment of atrophic acne scars.
Forty patients with atrophic acne scars (rolling, boxcar, and mixed types) were enrolled in a split-face study; microneedling was performed on both sides of the face followed by an application of topically diluted botulinum toxin on one side (Side A) and saline on the other (Side B) for two sessions both two weeks apart. Evaluation was done at baseline, two and four weeks after the session. Follow-up was performed after six months. The assessments included blinded clinical assessment and patient's satisfaction.
After the treatment, acne scars in (Side A) showed 70 percent overall improvement versus zero percent in Side B (<0.0001). A statistically highly significant reduction of acne scars severity occurred in (Side A) (=0.0008). Patient's satisfaction was higher in (Side A) (<0.0001). No serious side effects were reported.
Microneedling delivery of BTX-A could be simple, safe, and innovative modality improving the appearance and decrease the depth of atrophic acne scars.
痤疮瘢痕是大多数患者关注的美容问题。
我们旨在比较微针治疗（Mn）后立即局部应用A型肉毒毒素（BTX-A）与微针联合生理盐水治疗萎缩性痤疮瘢痕的临床疗效和安全性。
40例萎缩性痤疮瘢痕（滚轮状、箱车型和混合型）患者纳入一项半脸研究；在面部两侧进行微针治疗，随后一侧（A侧）局部应用稀释的肉毒毒素，另一侧（B侧）应用生理盐水，共进行两个疗程，疗程间隔两周。在基线、疗程后两周和四周进行评估。六个月后进行随访。评估包括盲法临床评估和患者满意度。
治疗后，（A侧）痤疮瘢痕总体改善率为70%，而（B侧）为0%（<0.0001）。（A侧）痤疮瘢痕严重程度有统计学意义的显著降低（=0.0008）。（A侧）患者满意度更高（<0.0001）。未报告严重副作用。
微针递送BTX-A可能是一种简单、安全且创新的方式，可改善萎缩性痤疮瘢痕的外观并减少其深度。
