Physical Education Department, Federal University of the Valleys of Jequitinhonha and Mucuri (UFVJM), Rodovia MGT 367 - Km 583, nº 5000, Bairro Alto da Jacuba, Diamantina, MG, CEP 39100-000, Brazil.
Neuroscience and Exercise Study Group (Grupo de Estudos em Neurociências e Exercício - GENE), UFVJM, Diamantina, MG, Brazil.
Neuromolecular Med. 2024 Jul 29;26(1):31. doi: 10.1007/s12017-024-08798-x.
The aim of this study was to evaluate the effects of swimming in the brain and behavior of young and aged mice. Forty-eight male C57BL/6 J mice were randomly distributed into 4 groups (n = 12 per group, 3 and 18 months old). The subdivision of the groups was: 3 months-SED, 18 months-SED, 3 months-EXE, and 18 months-EXE. SED mice did not swim, while EXE mice performed the physical exercise protocol. Training was initiated 48 h after the adaptation week. Swimming sessions consisted of 30 min, with no overload, 5 days per week, for 4 weeks. After the exercise protocol, it was revealed working and spatial memory were impaired in the 18 months-SED group. Pre- and post-synaptic proteins were enhanced in the groups that swam when compared to the 3- and 8 months-SED groups. Lipid peroxidation was greater in the aged mice that did not perform the physical exercise protocol and might have contributed to the cognitive impairment in this group. In conclusion, an aerobic physical exercise protocol, performed through regular swimming sessions, inhibited cognitive impairment, memory loss and lipid peroxidation in the aged mice, while pre- and post-synaptic proteins were enhanced in the hippocampus of young and aged mice.
本研究旨在评估游泳对年轻和老年小鼠大脑和行为的影响。48 只雄性 C57BL/6J 小鼠被随机分为 4 组（每组 n = 12，3 个月和 18 个月大）。分组情况如下：3 个月-SED、18 个月-SED、3 个月-EXE 和 18 个月-EXE。SED 组小鼠不游泳，而 EXE 组小鼠进行体育锻炼。适应性训练结束后 48 小时开始训练。游泳时间为 30 分钟，无过载，每周 5 天，持续 4 周。运动方案结束后，18 个月-SED 组的工作记忆和空间记忆受损。与 3 个月和 8 个月-SED 组相比，游泳组的突触前和突触后蛋白增加。未进行体育锻炼的老年小鼠的脂质过氧化作用更强，这可能导致该组认知障碍。总之，通过定期游泳，进行有氧运动方案可抑制老年小鼠的认知障碍、记忆丧失和脂质过氧化作用，同时增强年轻和老年小鼠海马区的突触前和突触后蛋白。
