Liu Yiting, Yang Rongfei, Zhang Nana, Liu Qingshan
Key Laboratory of Ethnomedicine of Ministry of Education, Center on Translational Neuroscience, School of Pharmacy, Minzu University of China, Beijing, China.
Braz J Psychiatry. 2024;46:e20243705. doi: 10.47626/1516-4446-2024-3705. Epub 2024 Jul 29.
Depression is a major public health problem. Many complementary and alternative medicine (CAM) interventions have been suggested as potential treatments. This umbrella review aimed to assess the efficacy and safety of CAM interventions for treating depression.
We comprehensively searched for relevant systematic reviews and meta-analyses in the MEDLINE (via PubMed), EMBASE, Web of Science, and Cochrane Library databases. We assessed effectiveness (based on efficacy and changes in depression assessment scale scores) and safety (based on adverse events).
A total of 22 eligible articles were included. Yueju antidepressant and electro-acupuncture (EA) improved depression symptoms better than conventional antidepressants. In addition, omega-3 fatty acids (n-3PUFAs), exercise, manual acupuncture (MA), Hypericum mono-preparations, relaxation, and vitamin D showed superior efficacy to placebo and controls. Guipi decotion (GPD) as adjunctive therapy has higher efficacy than conventional antidepressants, and MA and Yueju have a better safety profile than conventional antidepressants.
10 CAMs can effectively improve the condition of patients with clinical depression.
抑郁症是一个重大的公共卫生问题。许多补充和替代医学（CAM）干预措施已被提议作为潜在的治疗方法。本伞状综述旨在评估CAM干预措施治疗抑郁症的疗效和安全性。
我们全面检索了MEDLINE（通过PubMed）、EMBASE、科学网和考克兰图书馆数据库中的相关系统评价和荟萃分析。我们评估了有效性（基于疗效和抑郁评估量表分数的变化）和安全性（基于不良事件）。
共纳入22篇符合条件的文章。越鞠抗抑郁剂和电针（EA）比传统抗抑郁药能更好地改善抑郁症状。此外，ω-3脂肪酸（n-3PUFAs）、运动、手针（MA）、金丝桃属单一制剂、放松疗法和维生素D显示出比安慰剂和对照组更优的疗效。归脾汤（GPD）作为辅助疗法比传统抗抑郁药具有更高的疗效，且MA和越鞠比传统抗抑郁药具有更好的安全性。
10种补充和替代医学方法可有效改善临床抑郁症患者的病情。
