运动训练诱导的微小RNA改变对心血管疾病具有保护作用。
Exercise Training-Induced MicroRNA Alterations with Protective Effects in Cardiovascular Diseases.
作者信息
Gao Juan, Song Jiaxin, Yan Yuwei, Gokulnath Priyanka, Vulugundam Gururaja, Li Guoping, Zhan Qingyi, Jiang Fei, Lin Yanjuan, Xiao Junjie
机构信息
Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, 226011 Nantong, Jiangsu, China.
Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Life Science, Shanghai University, 200444 Shanghai, China.
出版信息
Rev Cardiovasc Med. 2023 Sep 6;24(9):251. doi: 10.31083/j.rcm2409251. eCollection 2023 Sep.
Exercise training (ET) is an important non-drug adjuvant therapy against many human diseases, including cardiovascular diseases. The appropriate ET intensity induces beneficial adaptions and improves physiological function and cardiopulmonary fitness. The mechanisms of exercise-induced cardioprotective effects are still not fully understood. However, mounting evidence suggest that microRNAs (miRNAs) play crucial role in this process and are essential in responding to exercise-stress and mediating exercise-protective effects. Thus, this review summarizes the biogenesis of miRNAs, the mechanism of miRNA action, and specifically the miRNAs involved in exercise-induced cardio-protection used as therapeutic targets for treating cardiovascular diseases.
运动训练（ET）是对抗包括心血管疾病在内的多种人类疾病的重要非药物辅助疗法。适当的运动训练强度可诱导有益的适应性变化，改善生理功能和心肺适能。运动诱导的心脏保护作用机制仍未完全明确。然而，越来越多的证据表明，微小RNA（miRNA）在这一过程中起关键作用，对于应对运动应激和介导运动保护作用至关重要。因此，本综述总结了miRNA的生物发生、miRNA作用机制，特别是参与运动诱导心脏保护作用的miRNA，这些miRNA可用作治疗心血管疾病的治疗靶点。
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