Department of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Endocrinol (Lausanne). 2024 Jul 15;15:1414350. doi: 10.3389/fendo.2024.1414350. eCollection 2024.
Bone homeostasis in physiology depends on the balance between bone formation and resorption, and in pathology, this homeostasis is susceptible to disruption by different influences, especially under ageing condition. Gut microbiota has been recognized as a crucial factor in regulating host health. Numerous studies have demonstrated a significant association between gut microbiota and bone metabolism through host-microbiota crosstalk, and gut microbiota is even an important factor in the pathogenesis of bone metabolism-related diseases that cannot be ignored. This review explores the interplay between gut microbiota and bone metabolism, focusing on the roles of gut microbiota in bone ageing and aging-related bone diseases, including osteoporosis, fragility fracture repair, osteoarthritis, and spinal degeneration from different perspectives. The impact of gut microbiota on bone metabolism during aging through modification of endocrinology system, immune system and gut microbiota metabolites are summarized, facilitating a better grasp of the pathogenesis of aging-related bone metabolic diseases. This review offers innovative insights into targeting the gut microbiota for the treatment of bone ageing-related diseases as a clinical therapeutic strategy.
在生理学中，骨骼的动态平衡依赖于骨形成和骨吸收之间的平衡，而在病理学中，这种平衡容易受到不同因素的干扰，尤其是在衰老的情况下。肠道微生物群已被认为是调节宿主健康的关键因素。大量研究表明，通过宿主-微生物群的相互作用，肠道微生物群与骨代谢之间存在显著关联，而且肠道微生物群甚至是骨代谢相关疾病发病机制中不可忽视的重要因素。本综述探讨了肠道微生物群与骨代谢之间的相互作用，重点关注肠道微生物群在骨衰老和与衰老相关的骨疾病中的作用，包括骨质疏松症、脆性骨折修复、骨关节炎和脊柱退化，从不同角度探讨了这一问题。综述总结了肠道微生物群通过内分泌系统、免疫系统和肠道微生物群代谢物对衰老过程中骨代谢的影响，有助于更好地掌握与衰老相关的骨代谢性疾病的发病机制。本综述为将靶向肠道微生物群作为一种临床治疗策略应用于治疗与骨衰老相关的疾病提供了创新性的见解。
