Bone Biology Laboratory, Department of Physiology, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
Bone Biology Laboratory, Department of Physiology, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
Bone. 2020 Jun;135:115317. doi: 10.1016/j.bone.2020.115317. Epub 2020 Mar 10.
The gut microbiota (GM) is referred to as the second gene pool of the human body and a commensal, symbiotic, and pathogenic microorganism living in our intestines. The knowledge of the complex interaction between intestinal microbiota and health outcomes is a novel and rapidly expanding the field. Earlier studies have reported that the microbial communities affect the cellular responses and shape many aspects of physiology and pathophysiology within the body, including muscle and bone metabolism (formation and resorption). GM influences the skeletal homeostasis via affecting the host metabolism, immune function, hormone secretion, and the gut-brain axis. The premise of this review is to discuss the role of GM on bone homeostasis and skeletal muscle mass function. This review also opens up new perspectives for pathophysiological studies by establishing the presence of a 'microbiota-skeletal' axis and raising the possibility of innovative new treatments for skeletal development.
肠道微生物群（GM）被称为人体的第二基因库，是一种共生、共生和致病微生物，存在于我们的肠道中。肠道微生物群与健康结果之间的复杂相互作用的知识是一个新颖且快速发展的领域。早期的研究报告称，微生物群落影响细胞反应，并塑造体内许多生理和病理生理学方面，包括肌肉和骨骼代谢（形成和吸收）。GM 通过影响宿主代谢、免疫功能、激素分泌和肠道-大脑轴来影响骨骼内的稳态。本综述的前提是讨论 GM 对骨骼内稳态和骨骼肌肉质量功能的作用。通过建立“微生物群-骨骼”轴，本综述为病理生理学研究开辟了新的视角，并为骨骼发育的创新新疗法提供了可能性。
