Division of Cardiac Surgery, Brigham and Women's Hospital, Boston, MA.
Circ Res. 2021 Apr 30;128(9):1398-1417. doi: 10.1161/CIRCRESAHA.121.318040. Epub 2021 Apr 29.
Aortic stenosis is the most common valvular disease requiring valve replacement. Valve replacement therapies have undergone progressive evolution since the 1960s. Over the last 20 years, transcatheter aortic valve replacement has radically transformed the care of aortic stenosis, such that it is now the treatment of choice for many, particularly elderly, patients. This review provides an overview of the pathophysiology, presentation, diagnosis, indications for intervention, and current therapeutic options for aortic stenosis.
主动脉瓣狭窄是最常见的需要瓣膜置换的瓣膜疾病。自 20 世纪 60 年代以来，瓣膜置换治疗经历了渐进式的发展。在过去的 20 年中，经导管主动脉瓣置换术彻底改变了主动脉瓣狭窄的治疗方法，使得它现在成为许多患者（尤其是老年患者）的首选治疗方法。本文综述了主动脉瓣狭窄的病理生理学、临床表现、诊断、介入治疗指征和当前的治疗选择。
