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硫丹的药理学、毒理学及降解 综述

Pharmacology, toxicology and degradation of endosulfan A review.

作者信息

Gupta P K, Gupta R C

出版信息

Toxicology. 1979 Jun-Jul;13(2):115-30.

PMID:390767
Abstract

This report presents a review of literature on organochlorine insecticide of the cyclodiene type endosulfan, which has been employed extensively for agricultural, domestic and public health purposes. It summarizes information on nomenclature and chemistry, metabolism and toxicity in mammals, birds, fishes and insects, degradation and metabolism in plants along with brief reference to the degradation in water and light. Unfortunately, because of lack of knowledge, a precise statement, in regard to the ecological implications and the quantitites of endosulfan now being used, is not possible at this time.

摘要

本报告对环二烯类有机氯杀虫剂硫丹的文献进行了综述,硫丹已广泛用于农业、家庭和公共卫生目的。它总结了有关硫丹的命名和化学、在哺乳动物、鸟类、鱼类和昆虫中的代谢与毒性、在植物中的降解和代谢等方面的信息,同时简要提及了其在水和光照下的降解情况。遗憾的是,由于知识有限,目前无法就硫丹的生态影响和当前使用量作出精确说明。

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1
Pharmacology, toxicology and degradation of endosulfan A review.硫丹的药理学、毒理学及降解 综述
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2
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[Comparative hygienic assessment of isomers and metabolites of endosulfan (review)].
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引用本文的文献

1
Oxidative stress-mediated cytotoxicity of Endosulfan is causally linked to the inhibition of NADH dehydrogenase and Na, K-ATPase in Ehrlich ascites tumor cells.硫丹诱导的氧化应激介导的细胞毒性与 NADH 脱氢酶和 Na+,K+-ATP 酶的抑制有关在艾氏腹水癌细胞。
Mol Cell Biochem. 2020 May;468(1-2):59-68. doi: 10.1007/s11010-020-03711-z. Epub 2020 Mar 16.
2
Endosulfan upregulates AP-1 binding and ARE-mediated transcription via ERK1/2 and p38 activation in HepG2 cells.硫丹通过 ERK1/2 和 p38 的激活上调 HepG2 细胞中 AP-1 结合和 ARE 介导的转录。
Toxicology. 2012 Feb 6;292(1):23-32. doi: 10.1016/j.tox.2011.11.013. Epub 2011 Nov 28.
3
Accumulation of endosulfan in wild rat, Rattus norvegious as a result of application to soya bean in Mazoe (Zimbabwe).
由于在津巴布韦马佐埃地区的大豆上施用硫丹,野生褐家鼠体内硫丹的蓄积情况。
Environ Monit Assess. 2007 Feb;125(1-3):333-45. doi: 10.1007/s10661-006-9526-9.
4
Oxygen radical generation and endosulfan toxicity in Jurkat T-cells.氧自由基生成与硫丹对人急性T淋巴细胞白血病细胞的毒性作用
Mol Cell Biochem. 2003 May;247(1-2):1-7. doi: 10.1023/a:1024172525123.
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Evidence for the induction of apoptosis by endosulfan in a human T-cell leukemic line.硫丹在人T细胞白血病细胞系中诱导细胞凋亡的证据。
Mol Cell Biochem. 2000 Feb;205(1-2):53-66. doi: 10.1023/a:1007080910396.
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The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants.作为识别雌激素工具的E-SCREEN检测法:雌激素性环境污染物的最新情况
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