每日一次与每日两次阿替洛尔治疗心绞痛的比较。

A comparison of once and twice daily atenolol for angina pectoris.

作者信息

Boyle R M, Bray C L, Naqvi N, Croxson R S, Cruickshank J M

出版信息

Int J Cardiol. 1983 Apr;3(1):25-35. doi: 10.1016/0167-5273(83)90058-x.

Abstract

We have studied the effects of four doses of atenolol in 11 patients with stable angina pectoris using a symptom-limited exercise test and angina diaries. The doses 100 mg twice daily and 50 mg, 100 mg and 200 mg once daily were given double-blind and randomised within patients following run-in on placebo. Measurements were made 12 hours after the last twice daily dose and 24 hours after the last once daily dose. Exercise tolerance was improved by 40-74% and exercise duration before the onset of angina by 61-94% (P less than 0.01). Maximal heart rate was reduced further by a total daily dose of 200 mg than by lower doses, but no extra benefit was derived by giving the drug twice daily. The largest increase in exercise tolerance was obtained during treatment with 50 mg once daily. Atenolol was shown to be an effective anti-anginal agent when given once daily, and there were no major differences between the doses studied.

摘要

我们使用症状限制性运动试验和心绞痛日记，研究了四种剂量的阿替洛尔对11例稳定型心绞痛患者的影响。在服用安慰剂进行导入期后，患者被双盲随机给予每日两次100 mg以及每日一次50 mg、100 mg和200 mg的剂量。在每日两次给药的最后一剂后12小时以及每日一次给药的最后一剂后24小时进行测量。运动耐量提高了40 - 74%，心绞痛发作前的运动持续时间提高了61 - 94%（P小于0.01）。与较低剂量相比，每日总剂量200 mg能进一步降低最大心率，但每日两次给药并未带来额外益处。每日一次服用50 mg治疗期间运动耐量增加最大。结果表明，阿替洛尔每日一次给药时是一种有效的抗心绞痛药物，且所研究的剂量之间无重大差异。