Girma Abayeneh, Genet Amere
Department of Biology, College of Natural and Computational Science, Mekdela Amba University, P.O. Box 32, Tulu Awuliya, Ethiopia.
Parasite Epidemiol Control. 2024 Jul 8;26:e00368. doi: 10.1016/j.parepi.2024.e00368. eCollection 2024 Aug.
Intestinal parasitic infections (IPIs) pose a serious public health threat across the globe, particularly in children residing in poor and most deprived communities like Ethiopia. Many published articles were available separately, and a detailed nationwide review was essential to combine all the results to draw a conclusion and avoid any informational conflicts, ambiguities, or misunderstandings. Therefore, this systematic review and meta-analysis aimed to provide pooled estimates for the individually available data on IPIs and its determinant factors among preschool-aged children (PSAC) in Ethiopia. Published and unpublished articles from various electronic databases were accessed using MeSH terms and keywords. and sensitivity analysis tests were used to assess potential sources of heterogeneity across studies. Funnel plot, Begg's, and Egger's regression tests were used to check publication bias. A random-effects model with a 95% confidence interval (CI) was used to calculate the pooled estimate of IPI. In this meta-analysis, a total of 14,994 PSAC were included in the 32 eligible studies. The pooled national prevalence of IPIs among PSAC was 32.52% (95% CI: 26.24, 38.80). Of these, single and mixed infections contribute 31.08% and 1.44%, respectively. According to the subgroup analysis, the highest prevalence was observed in simple random studies (39.61%; 95% CI: 29.19, 50.03), the Tigray region (58.00%; 95% CI: 54.10, 61.90), studies conducted in >384 (39.47%; 95% CI: 27.73, 51.20) sample sizes, cross-sectional studies (32.76%), community-based studies (42.33%; 95% CI: 31.93, 52.74), and from 2005 to 2016 (34.53%; 95% CI: 20.13, 48.92) study periods. Intestinal parasites were significantly associated with eating raw fruits and vegetables (aOR = 3.21; 95%CI: 1.11-5.31). The high prevalence of STHs observed in this systematic review and meta-analysis underscores the need for appropriate control and prevention strategies suitable for PSAC in Ethiopia.
肠道寄生虫感染（IPIs）在全球范围内构成严重的公共卫生威胁，尤其是在居住在像埃塞俄比亚这样贫困和最贫困社区的儿童中。许多已发表的文章是分散的，进行详细的全国性综述对于整合所有结果以得出结论并避免任何信息冲突、模糊或误解至关重要。因此，本系统综述和荟萃分析旨在为埃塞俄比亚学龄前儿童（PSAC）中IPIs及其决定因素的单独可用数据提供汇总估计。使用医学主题词（MeSH）术语和关键词检索了来自各种电子数据库的已发表和未发表文章。并使用敏感性分析测试来评估各研究间潜在的异质性来源。采用漏斗图、Begg检验和Egger回归检验来检查发表偏倚。使用具有95%置信区间（CI）的随机效应模型来计算IPIs的汇总估计值。在这项荟萃分析中，32项符合条件的研究共纳入了14,994名PSAC。PSAC中IPIs的全国汇总患病率为32.52%（95%CI：26.24，38.80）。其中，单一感染和混合感染分别占31.08%和1.44%。根据亚组分析，在简单随机研究（39.61%；95%CI：29.19，50.03）、提格雷地区（58.00%；95%CI：54.10，61.90）、样本量>384的研究（39.47%；95%CI：27.73，51.20）、横断面研究（32.76%）、基于社区的研究（42.33%；95%CI：31.93，52.74）以及2005年至2016年的研究期间（34.53%；95%CI：20.13，48.92）中观察到的患病率最高。肠道寄生虫与食用生水果和蔬菜显著相关（调整后比值比[aOR]=3.21；95%CI：1.11 - 5.31）。在本系统综述和荟萃分析中观察到的土源性蠕虫高患病率凸显了在埃塞俄比亚制定适合PSAC的适当控制和预防策略的必要性。
