Tadele Tafese, Astatkie Ayalew, Abay Solomon Mequanente, Tadesse Birkneh Tilahun, Makonnen Eyasu, Aklillu Eleni
School of Public Health, College of Medicine and Health Sciences, Hawassa University, Hawassa P.O. Box 1560, Ethiopia.
Department of Pharmacology and Clinical Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa P.O. Box 9086, Ethiopia.
Pathogens. 2023 Jun 21;12(7):858. doi: 10.3390/pathogens12070858.
School-based deworming program is implemented to control and eliminate infection in many endemic countries, including Ethiopia. However, pre-school-age children (pre-SAC) are not targeted to receive preventive chemotherapy against infection, partly due to a lack of information on the disease burden. We assessed the prevalence and correlates of infection among pre-SAC in Southern Ethiopia. A total of 1683 pre-SAC aged 4 to 7 years were screened for infection. A multilevel binary logistic regression was fitted to detect the significant determinants of infection. Adjusted odds ratios (AORs) with a 95% confidence interval (CI) were used to identify determinants of infection. The overall prevalence of infection was 14.3% (95% CI: 12.6, 16.0%). infection was significantly higher among 6-year-old (AOR = 2.58, 95% CI: 1.55, 4.27) and 7-year-old children (AOR = 4.63, 95% CI: 2.82, 7.62). Accompanying others to water sources sometimes (AOR = 2.60, 95% CI: 1.12, 6.01) and all the time (AOR = 5.91, 95% CI: 2.51, 13.90), and residing in less than one kilometer from the infested water source (AOR = 3.17, 95% CI: 1.47, 6.83) increased the odds of infection. In conclusion, the prevalence of infection among pre-SAC in the study area was moderate. The study highlights the urgent need to include pre-SAC aged 4 to 7 years in annual preventive chemotherapy campaigns to reduce the risk of possible sources of infection and enhance the achievement of the elimination target.
包括埃塞俄比亚在内的许多流行国家实施了以学校为基础的驱虫计划,以控制和消除感染。然而,学龄前儿童(SAC前)未被纳入接受针对感染的预防性化疗对象,部分原因是缺乏关于疾病负担的信息。我们评估了埃塞俄比亚南部SAC前儿童中感染的患病率及其相关因素。共对1683名4至7岁的SAC前儿童进行了感染筛查。采用多水平二元逻辑回归来检测感染的重要决定因素。使用调整后的比值比(AOR)和95%置信区间(CI)来确定感染的决定因素。感染的总体患病率为14.3%(95%CI:12.6,16.0%)。6岁儿童(AOR = 2.58,95%CI:1.55,4.27)和7岁儿童(AOR = 4.63,95%CI:2.82,7.62)的感染率显著更高。有时(AOR = 2.60,95%CI:1.12,6.01)或总是(AOR = 5.91,95%CI:2.51,13.90)陪同他人前往水源地,以及居住在距离受感染水源不到一公里处(AOR = 3.17,95%CI:1.47,6.83)会增加感染几率。总之,研究区域内SAC前儿童的感染患病率处于中等水平。该研究强调迫切需要将4至7岁的SAC前儿童纳入年度预防性化疗活动,以降低可能的感染源风险并促进消除目标的实现。