Inoue Mika, Kubota Atsushi, Takazawa Yuji, Nakagawara Kosuke, Ishige Kazuya, Suzuki Yoshio
Juntendo Administration for Sports, Health and Medical Sciences, Juntendo University, Tokyo, Japan.
Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan.
Front Sports Act Living. 2024 Jul 15;6:1403215. doi: 10.3389/fspor.2024.1403215. eCollection 2024.
A short period of disuse of 1-2 weeks due to factors such as illness or injury can lead to muscle atrophy, affecting both athletic performance and health. Recent research has shown that uridine 5'-monophosphate (5'-UMP) can counteract disuse-induced muscle atrophy by increasing PGC-1α expression and inhibiting atrogin-1 expression. However, the effect of 5'-UMP on disuse muscle atrophy in humans remains unknown. Therefore, the aimed of this study was to explore the effects of 5'-UMP supplementation during detraining on short-term disuse muscle atrophy in healthy men.
Following a 6-week resistance training program on upper arm, healthy men were randomized to either a UMP group ( = 11) or a placebo group ( = 10), taking their respective supplements during the 2-week detraining period. Muscle thickness, an indicator of muscle hypertrophy and atrophy, was measured at 3 positions (MT50, MT60, and MT70) at baseline, 1 week, and 2 weeks after detraining.
Both groups showed a significant decrease in muscle thickness at MT70. The relative decrease was greater in the placebo group (2.4 ± 2.8%) than in the UMP group (0.0 ± 2.0%), significantly ( = 0.034) at 1 week. However, no significant difference was observed at MT50 and MT60.
After the hypertrophy, 5'-UMP may prevent muscle atrophy due to the detraining within the first week.
因疾病或受伤等因素导致1至2周的短期废用会引发肌肉萎缩，影响运动表现和健康。近期研究表明，5'-单磷酸尿苷（5'-UMP）可通过增加PGC-1α表达和抑制肌萎缩蛋白-1表达来对抗废用性肌肉萎缩。然而，5'-UMP对人类废用性肌肉萎缩的影响尚不清楚。因此，本研究旨在探讨在停训期间补充5'-UMP对健康男性短期废用性肌肉萎缩的影响。
在上臂进行为期6周的抗阻训练计划后，健康男性被随机分为UMP组（n = 11）和安慰剂组（n = 10），在为期2周的停训期间服用各自的补充剂。在停训前、停训1周和2周时，在3个位置（MT50、MT60和MT70）测量肌肉厚度，这是肌肉肥大和萎缩的一个指标。
两组在MT70处的肌肉厚度均显著下降。安慰剂组的相对下降幅度（2.4±2.8%）大于UMP组（0.0±2.0%），在第1周时差异有统计学意义（P = 0.034）。然而，在MT50和MT60处未观察到显著差异。
在肌肉肥大后，5'-UMP可能在第一周内预防因停训导致的肌肉萎缩。
