Behboudi-Gandevani Samira, Arntzen Ellen Christin, Normann Britt, Haugan Tommy, Bidhendi-Yarandi Razieh
Faculty of Nursing and Health Sciences, Nord University, 8049 Bodø, Norway.
Faculty of Nursing and Health Sciences, Nord University, 7629 Levanger, Norway.
Rev Cardiovasc Med. 2023 Jul 4;24(7):193. doi: 10.31083/j.rcm2407193. eCollection 2023 Jul.
It is well documented that menopause is linked to an increased risk of cardiovascular (CV) events; however, the results of studies focusing on the association between premature ovarian insufficiency (POI) and the risk of CV events are controversial. The aim of this systematic review and meta-analysis was to assess the risk of CV events among women with POI compared to women with menopausal aged 50-54 years.
A systematic literature search of PubMed (including Medline), Scopus, and Web of Science was conducted from 1990 to 2022 to retrieve observational studies published in English-language. The studies' quality was assessed using structured standard tools. Primary-outcome was the pooled risk of the composite outcome of CV events.
We included 16 studies involving 40,549 women who suffered from POI and 1,016,633 women as controls. After adjustment for hormone therapy, the pooled risk of composite outcome of CV events and coronary heart disease, among women with the POI was significantly 1.3 (Pooled-adjusted hazard ratio (HR) = 1.35, 95% CI: 1.06-1.63, : 0%) and 1.4 (Pooled adjusted HR = 1.42, 95% CI: 1.17-1.66, : 0%) fold higher than women with menopausal age 50-54 years. There was no difference between the groups regarding the risk of stroke and death due to CV events between two groups. There was not sufficient data for pooled analysis of other specific CV events.
In conclusion, POI is associated with an increased risk of CV events, particularly coronary heart disease. Our findings extend prior work with data supporting POI as a risk-enhancing factor for CV events. However, more studies are needed to confirmed these findings.
有充分证据表明，更年期与心血管（CV）事件风险增加有关；然而，关注卵巢早衰（POI）与CV事件风险之间关联的研究结果存在争议。本系统评价和荟萃分析的目的是评估POI女性与50 - 54岁更年期女性相比发生CV事件的风险。
对1990年至2022年期间的PubMed（包括Medline）、Scopus和Web of Science进行系统文献检索，以获取英文发表的观察性研究。使用结构化标准工具评估研究质量。主要结局是CV事件复合结局的合并风险。
我们纳入了16项研究，涉及40549名患有POI的女性和1016633名女性作为对照。在调整激素治疗后，POI女性中CV事件和冠心病复合结局的合并风险显著高于50 - 54岁更年期女性，分别为1.3倍（合并调整后风险比（HR）= 1.35，95%置信区间：1.06 - 1.63，P = 0%）和1.4倍（合并调整后HR = 1.42，95%置信区间：1.17 - 1.66，P = 0%）。两组之间在中风风险和CV事件导致的死亡风险方面没有差异。没有足够的数据对其他特定CV事件进行合并分析。
总之，POI与CV事件风险增加有关，尤其是冠心病。我们的研究结果扩展了先前的工作，数据支持POI作为CV事件的风险增强因素。然而，需要更多研究来证实这些发现。
