Baghani Matin, Fathalizade Farzan, Loghman Amir Hossein, Samieefar Noosha, Ghobadinezhad Farbod, Rashedi Ronak, Baghsheikhi Hediyeh, Sodeifian Fatemeh, Rahimzadegan Milad, Akhlaghdoust Meisam
Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Sci One Health. 2023 Nov 14;2:100048. doi: 10.1016/j.soh.2023.100048. eCollection 2023.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has taken a toll on humans, and the development of effective vaccines has been a promising tool to end the pandemic. However, for a vaccination program to be successful, a considerable proportion of the community must be vaccinated. Hence, public acceptance of coronavirus disease 2019 (COVID-19) vaccines has become the key to controlling the pandemic. Recent studies have shown vaccine hesitancy increasing over time. This systematic review aims to evaluate the COVID-19 vaccine hesitancy rate and related factors in different communities.
A comprehensive search was performed in MEDLINE (via PubMed), Scopus, and Web of Science from January 1, 2019 to January 31, 2022. All relevant descriptive and observational studies (cross-sectional and longitudinal) on vaccine hesitancy and acceptance were included in this systematic review. In the meta-analysis, odds ratio (OR) was used to assess the effects of population characteristics on vaccine hesitancy, and event rate (acceptance rate) was the effect measure for overall acceptance. Publication bias was assessed using the funnel plot, Egger's test, and trim-and-fill methods.
A total of 135 out of 6,417 studies were included after screening. A meta-analysis of 114 studies, including 849,911 participants, showed an overall acceptance rate of 63.1%. In addition, men, married individuals, educated people, those with a history of flu vaccination, those with higher income levels, those with comorbidities, and people living in urban areas were less hesitant.
Increasing public awareness of the importance of COVID-19 vaccines in overcoming the pandemic is crucial. Being men, living in an urban region, being married or educated, having a history of influenza vaccination, having a higher level of income status, and having a history of comorbidities are associated with higher COVID-19 vaccine acceptance.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）大流行给人类带来了巨大损失，开发有效的疫苗一直是终结这场大流行的一个有前景的工具。然而，要使疫苗接种计划取得成功，相当大比例的社区成员必须接种疫苗。因此，公众对2019冠状病毒病（COVID-19）疫苗的接受程度已成为控制大流行的关键。最近的研究表明，疫苗犹豫情绪随着时间的推移而增加。本系统评价旨在评估不同社区中COVID-19疫苗犹豫率及相关因素。
于2019年1月1日至2022年1月31日在医学期刊数据库（通过PubMed）、Scopus和科学网进行了全面检索。所有关于疫苗犹豫和接受情况的相关描述性和观察性研究（横断面研究和纵向研究）均纳入本系统评价。在荟萃分析中，比值比（OR）用于评估人群特征对疫苗犹豫的影响，事件发生率（接受率）是总体接受情况的效应指标。采用漏斗图、埃格检验和修剪填充法评估发表偏倚。
经过筛选，6417项研究中共有135项被纳入。对114项研究（包括849911名参与者）的荟萃分析显示，总体接受率为63.1%。此外，男性、已婚者、受过教育的人、有流感疫苗接种史的人、收入水平较高的人、患有合并症的人以及居住在城市地区的人疫苗犹豫程度较低。
提高公众对COVID-19疫苗在战胜大流行中重要性的认识至关重要。男性、居住在城市地区、已婚或受过教育、有流感疫苗接种史、收入水平较高以及有合并症病史与较高的COVID-19疫苗接受度相关。
