Mnajjed Lana, Fassina Grace, Li Hanxia, Patel Rusha J
University of Oklahoma Department of Surgery-Tulsa Tulsa Oklahoma USA.
University of Oklahoma College of Medicine Oklahoma City Oklahoma USA.
Laryngoscope Investig Otolaryngol. 2025 Jul 16;10(4):e70201. doi: 10.1002/lio2.70201. eCollection 2025 Aug.
To assess the relationship between COVID and HPV vaccine hesitancy among oropharyngeal cancer patients and the effects of the pandemic on vaccine hesitancy.
A 25-question survey was developed to assess patient demographics, background information, and attitudes towards both the HPV and COVID-19 vaccines. The survey was administered in person to patients with a history of p16+ oropharyngeal squamous cell carcinoma (OPSCC). Results were statistically analyzed for significant associations between various factors relating to hesitancy.
A high school education or higher was significantly associated with patients who would recommend the COVID-19 vaccine to others and trust their health care provider's recommendations about COVID-19 vaccination. Education was only a significant factor with regard to HPV vaccination when patients were asked about vaccination restricting their autonomy. Several significant associations were found between similar attitudes towards both the COVID-19 vaccine and HPV vaccine, including safety, autonomy, concerns about government intervention, and likelihood of vaccine recommendation. No significant association was found between the pandemic and change in views on vaccination.
Although the COVID-19 pandemic did not seem to affect many OPSCC patients' views on vaccination one way or another, we did uncover similar trends in vaccine hesitancy between the newer COVID-19 vaccine and older HPV vaccine. Our results indicate that established safety and history of a vaccine are likely very minor players in vaccine hesitancy, and efforts toward vaccine acceptance should be focused on patient background factors, including education and trust.
评估口咽癌患者中新冠病毒（COVID）与HPV疫苗犹豫之间的关系，以及疫情对疫苗犹豫的影响。
设计了一份包含25个问题的调查问卷，以评估患者的人口统计学信息、背景信息以及对HPV疫苗和新冠疫苗的态度。该问卷由有p16+口咽鳞状细胞癌（OPSCC）病史的患者当面填写。对与犹豫相关的各种因素之间的显著关联进行了统计分析。
高中及以上学历与那些会向他人推荐新冠疫苗并信任其医疗服务提供者关于新冠疫苗接种建议的患者显著相关。当询问患者疫苗接种是否限制其自主权时，教育程度才是与HPV疫苗接种相关的一个显著因素。在对新冠疫苗和HPV疫苗的类似态度之间发现了几个显著关联，包括安全性、自主权、对政府干预的担忧以及推荐疫苗的可能性。未发现疫情与疫苗接种观点变化之间存在显著关联。
尽管新冠疫情似乎并未以任何方式影响许多OPSCC患者对疫苗接种的看法，但我们确实发现了较新的新冠疫苗和较旧的HPV疫苗在疫苗犹豫方面存在类似趋势。我们的结果表明，已确立的疫苗安全性和接种史在疫苗犹豫中可能作用甚微，提高疫苗接受度的努力应集中在患者背景因素上，包括教育程度和信任度。
