Chen Yue-Lai, Yang Ming, Tian Yu, Chen Xiao-Xu, Lu Wei, Wei Hua-Feng, Wang Xiao, Li Jiao, Zhu Dong, Zhang Shun-Xian
Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Sci One Health. 2023 Oct 31;2:100049. doi: 10.1016/j.soh.2023.100049. eCollection 2023.
The holistic view of the 'The unity of man and nature' promotes the development and application of traditional Chinese medicine (TCM). Despite the absence of modern pharmacological therapies with robust efficacy against coronavirus disease 2019 (COVID-19), TCM has exhibited potential utility for treating the disease in clinical practice.
A retrospective cohort study was conducted to investigate the therapeutic effect of TCM treatment intensity (TCMTI) in patients with mild COVID-19. A total of 6120 laboratory-confirmed patients with mild COVID-19 were recruited from temporary isolation facilities. The primary outcome measure was severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ribonucleic acid conversion time. In addition, restricted cubic spline models were employed to elucidate nonlinear relationships.
The median age (range) of the study participants was 43.0 (2.0-75.0) years, with a median hospitalization duration of 9.7 (4.1-22.5) days. The median time for achieving SARS-CoV-2 ribonucleic acid negativity was 6.67 days. The restricted cubic spline models revealed a remarkable nonlinear association between TCMTI and the time-to-ribonucleic acid negativity. After adjusting for potential confounders, the high TCMTI group exhibited a markedly shorter median time to SARS-CoV-2 ribonucleic acid negativity and reduced hospitalization duration ( < 0.001) than the low TCMTI group. Moreover, the mean time to achieve SARS-CoV-2 ribonucleic acid negativity was shortened by 1.909 days ( < 0.001) in the high-TCMTI group compared to the low-TCMTI group.
This study suggests that early initiation and intensified use of TCM may accelerate the time required to achieve SARS-CoV-2 ribonucleic acid negativity in patients with COVID-19, bearing considerable implications for public health.
“天人合一”的整体观推动了中医的发展与应用。尽管缺乏对2019冠状病毒病（COVID-19）有强大疗效的现代药理疗法，但中医在临床实践中已展现出治疗该疾病的潜在效用。
进行一项回顾性队列研究，以调查中医治疗强度（TCMTI）对轻度COVID-19患者的治疗效果。从临时隔离设施中招募了6120例实验室确诊的轻度COVID-19患者。主要结局指标为严重急性呼吸综合征冠状病毒2（SARS-CoV-2）核糖核酸转换时间。此外，采用受限立方样条模型来阐明非线性关系。
研究参与者的年龄中位数（范围）为43.0（2.0 - 75.0）岁，住院时间中位数为9.7（4.1 - 22.5）天。实现SARS-CoV-2核糖核酸转阴的中位时间为6.67天。受限立方样条模型显示TCMTI与核糖核酸转阴时间之间存在显著的非线性关联。在调整潜在混杂因素后，高TCMTI组与低TCMTI组相比，SARS-CoV-2核糖核酸转阴的中位时间显著缩短，住院时间也缩短（<0.001）。此外，高TCMTI组实现SARS-CoV-2核糖核酸转阴的平均时间比低TCMTI组缩短了1.909天（< 0.001）。
本研究表明，早期启动并强化使用中医可能会加速COVID-19患者实现SARS-CoV-2核糖核酸转阴所需的时间，对公共卫生具有重要意义。
