Bai Yaya, Jia Huiying, Avolio Alberto, Qian Yi, Zuo Junli
Department of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.
Rev Cardiovasc Med. 2023 Feb 2;24(2):41. doi: 10.31083/j.rcm2402041. eCollection 2023 Feb.
Carotid-femoral pulse wave velocity (cfPWV) and ejection duration (ED) have different impacts on target organ damage (TOD). The aim of this study was to determine the relationship of cfPWV and ED with TOD.
A total of 1254 patients (64.27% males) from Ruijin Hospital were enrolled in this study from December 2018 to August 2022. Medical records, blood samples and urine samples were collected. The cfPWV was measured and ED was generated using SphygmoCor software (version 8.0, AtCor Medical, Sydney, Australia). TOD including left ventricular hypertrophy (LVH), microalbuminuria, chronic kidney disease (CKD), and abnormality of carotid intima-media thickness (CIMT) were evaluated.
Multiple stepwise linear regression models of cfPWV and ED (individually or together) showed that cfPWV was positively correlated with left ventricular mass index (LVMI) ( = 0.131, = 0.002) and Log (albumin-creatinine ratio, ACR) ( = 0.123, = 0.004), while ED was negatively correlated with LVMI ( = -0.244, 0.001) and positively correlated with the estimated glomerular filtration rate (eGFR) ( = 0.115, = 0.003). When cfPWV and ED were added separately or together in multiple stepwise logistic regression models, cfPWV was associated with CKD [odds ratio (OR) = 1.240, 95% confidence interval (CI) 1.055-1.458, = 0.009], while ED was associated with LVH (OR = 0.983, 95% CI 0.975-0.992, 0.001). In the control group with normal cfPWV and normal ED, LVH was significantly lower in patients with high ED (OR = 0.574, 95% CI 0.374-0.882, = 0.011), but significantly elevated in those with high cfPWV and low ED (OR = 6.799, 95% CI 1.305-35.427, = 0.023).
cfPWV was more strongly associated with renal damage, while ED was more strongly associated with cardiac dysfunction. cfPWV and ED affect each other, and together have an effect on LVH.
颈股脉搏波速度（cfPWV）和射血持续时间（ED）对靶器官损害（TOD）有不同影响。本研究旨在确定cfPWV和ED与TOD之间的关系。
2018年12月至2022年8月，共有1254例来自瑞金医院的患者（男性占64.27%）纳入本研究。收集病历、血液样本和尿液样本。使用SphygmoCor软件（版本8.0，AtCor Medical，悉尼，澳大利亚）测量cfPWV并生成ED。评估包括左心室肥厚（LVH）、微量白蛋白尿、慢性肾脏病（CKD）和颈动脉内膜中层厚度（CIMT）异常在内的TOD。
cfPWV和ED（单独或一起）的多元逐步线性回归模型显示，cfPWV与左心室质量指数（LVMI）呈正相关（β = 0.131，P = 0.002）和与对数（白蛋白 - 肌酐比值，ACR）呈正相关（β = 0.123，P = 0.004），而ED与LVMI呈负相关（β = -0.244，P < 0.001）且与估算肾小球滤过率（eGFR）呈正相关（β = 0.115，P = 0.003）。当cfPWV和ED分别或一起加入多元逐步逻辑回归模型时，cfPWV与CKD相关[比值比（OR）= 1.240，95%置信区间（CI）1.055 - 1.458，P = 0.009]，而ED与LVH相关（OR = 0.983，95% CI 0.975 - 0.992，P < 0.001）。在cfPWV和ED均正常的对照组中，ED高的患者LVH显著降低（OR = 0.574，95% CI 0.374 - 0.882，P = 0.011），但cfPWV高且ED低的患者LVH显著升高（OR = 6.799，95% CI 1.305 - 35.427，P = 0.023）。
cfPWV与肾脏损害的关联更强，而ED与心脏功能障碍的关联更强。cfPWV和ED相互影响，并共同对LVH产生作用。
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