Laboratory of Functional Microbiology and Animal Health, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China.
Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control, Henan University of Science and Technology, Luoyang, China.
Front Cell Infect Microbiol. 2024 Jul 15;14:1420854. doi: 10.3389/fcimb.2024.1420854. eCollection 2024.
Numerous tripartite motif (TRIM) proteins, identified as E3 ubiquitin ligases, participate in various viral infections through ubiquitylation, ISGylation, and SUMOylation processes. Respiratory viruses, particularly influenza A virus (IAV) and respiratory coronaviruses (CoVs), have severely threatened public health with high morbidity and mortality, causing incalculable losses. Research on the regulation of TRIM proteins in respiratory virus infections is crucial for disease prevention and control. This review introduces TRIM proteins, summarizes recent discoveries regarding their roles and molecular mechanisms in IAV and CoVs infections, discusses current research gaps, and explores potential future trends in this rapidly developing field. It aims to enhance understanding of virus-host interactions and inform the development of new molecularly targeted therapies.
大量的三联基序（TRIM）蛋白被鉴定为 E3 泛素连接酶，通过泛素化、ISG 化和 SUMO 化过程参与各种病毒感染。呼吸道病毒，特别是甲型流感病毒（IAV）和呼吸道冠状病毒（CoVs），具有高发病率和死亡率，严重威胁着公众健康，造成了不可估量的损失。研究 TRIM 蛋白在呼吸道病毒感染中的调控对于疾病的预防和控制至关重要。本综述介绍了 TRIM 蛋白，总结了它们在 IAV 和 CoVs 感染中的作用和分子机制的最新发现，讨论了当前的研究空白，并探讨了这个快速发展领域的潜在未来趋势。旨在增强对病毒-宿主相互作用的理解，并为新型分子靶向治疗提供信息。
