Karaipoom Pathom, Saengsawang Phirabhat, Bromnavej Arisa, Sangsong Supattra, Waseewiwat Pinkamon, Bunsanong Bunrit, Nissapatorn Veeranoot, Pereira Maria de Lourdes, Mitsuwan Watcharapong
Office of Disease Prevention and Control Region 11, Nakhon Si Thammarat, 80000, Thailand.
Akkhraratchakumari Veterinary College, Walailak University, Nakhon Si Thammarat, 80160, Thailand.
Vet World. 2024 Jun;17(6):1405-1412. doi: 10.14202/vetworld.2024.1405-1412. Epub 2024 Jun 28.
causes global concern with tuberculosis (TB). Multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) pose additional challenges, as they resist to multiple first-line drugs. This study investigated the occurrence of TB, antibiotic resistance due to and gene mutations, and multidrug resistance in during fiscal years 2020-2022.
Samples were gathered from hospitals in seven provinces of upper Southern Thailand. The study investigated the correlation between and gene mutations in and the development of antimicrobial resistance and isoniazid resistance.
A total of 19,186 samples were sent to the Office of Disease Prevention and Control Region 11, Nakhon Si Thammarat, Thailand. The results showed that 51% of the samples were obtained from patients located in Nakhon Si Thammarat, followed by Surat Thani provinces. Regarding the spatial distribution of TB-infected cases, the incidence of TB was high in the province, which has a moderate to high population density. The highest average occurrence of TB in this study was found in Phuket province (9.75/100,000 risk person-year). The detected isoniazid resistance was 394, 255, and 179 cases in 2020, 2021, and 2022, respectively. A total of 99 isolates were MDR, whereas four isolates were XDR. The antimicrobial resistance associated with the mutation was 192, 142, and 105 isolates, respectively, whereas the resistance associated with the mutation was 249, 182, and 120 cases in 2020, 2021, and 2022, respectively.
These findings contribute to the understanding of the occurrence of antibiotic-resistant TB that could lead to use as data for preventing MDR-TB.
结核病引起全球关注。耐多药结核病（MDR-TB）和广泛耐药结核病（XDR-TB）带来了额外挑战，因为它们对多种一线药物耐药。本研究调查了2020 - 2022财年泰国南部上游七个省份结核病的发生情况、因 和 基因突变导致的抗生素耐药性以及耐多药情况。
从泰国南部上游七个省份的医院收集样本。该研究调查了 中 和 基因突变与抗菌药物耐药性及异烟肼耐药性发展之间的相关性。
总共19186份样本被送往泰国那空是贪玛叻疾病预防与控制区域11办公室。结果显示，51%的样本来自那空是贪玛叻的患者，其次是素叻他尼府。关于结核病感染病例的空间分布，在人口密度中等至高的省份结核病发病率较高。本研究中结核病平均发生率最高的是普吉府（9.75/100,000风险人年）。2020年、2021年和2022年检测到的异烟肼耐药病例分别为394例、255例和179例。共有99株分离株为耐多药，而4株分离株为广泛耐药。与 基因突变相关的抗菌药物耐药性分别为192株、142株和105株，而与 基因突变相关的耐药性在2020年、2021年和2022年分别为249例、182例和120例。
这些发现有助于了解耐抗生素结核病的发生情况，可为预防耐多药结核病提供数据。
