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大鼠柯蒂氏器中降钙素基因相关肽的定位:一项免疫组织化学研究。

Localization of calcitonin gene-related peptide in the organ of Corti of the rat: an immunohistochemical study.

作者信息

Kitajiri M, Yamashita T, Tohyama Y, Kumazawa T, Takeda N, Kawasaki Y, Matsunaga T, Girgis S, Hillyard C J, MacIntyre I

出版信息

Brain Res. 1985 Dec 9;358(1-2):394-7. doi: 10.1016/0006-8993(85)90992-8.

DOI:10.1016/0006-8993(85)90992-8
PMID:3907750
Abstract

The localization of calcitonin gene-related peptide (CGRP)-like immunoreactive (CGRPI) structures in the cochlea was examined in the rat using immunocytochemistry. Numerous CGRPI fibers entered the organ of Corti in the intraganglionic spiral bundle and formed a dense fiber patch at the base of the inner hair cells. Much fewer, but still a significant number of CGRPI fibers were seen at the synaptic region of the outer hair cells. Since no immunoreactive cells were seen in the organ of Corti and spinal ganglion, these fibers may be one of the major components of the olivocochlear bundles originated from the superior olivary complex.

摘要

采用免疫细胞化学方法,在大鼠中研究了降钙素基因相关肽(CGRP)样免疫反应性(CGRPI)结构在耳蜗中的定位。大量CGRPI纤维通过神经节内螺旋束进入柯蒂氏器,并在内毛细胞基部形成密集的纤维斑。在外毛细胞的突触区域也可见到数量少得多但仍相当可观的CGRPI纤维。由于在柯蒂氏器和脊髓神经节中未见到免疫反应性细胞,这些纤维可能是源自上橄榄复合体的橄榄耳蜗束的主要成分之一。

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Localization of calcitonin gene-related peptide in the organ of Corti of the rat: an immunohistochemical study.大鼠柯蒂氏器中降钙素基因相关肽的定位:一项免疫组织化学研究。
Brain Res. 1985 Dec 9;358(1-2):394-7. doi: 10.1016/0006-8993(85)90992-8.
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Electron microscopic observation of calcitonin gene-related peptide-like immunoreactivity in the organ of Corti of the rat.大鼠柯蒂氏器中降钙素基因相关肽样免疫反应性的电子显微镜观察
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The presence of a calcitonin gene-related peptide in the olivocochlear bundle in rat.大鼠橄榄耳蜗束中降钙素基因相关肽的存在。
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Several distinct receptor binding enkephalins in olivocochlear fibers and terminals in the organ of Corti.在橄榄耳蜗纤维以及柯蒂氏器终末中有几种不同的与受体结合的脑啡肽。
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Enkephalin-like immunoreactivity of olivocochlear nerve fibers in cochlea of guinea pig and cat.豚鼠和猫耳蜗中橄榄耳蜗神经纤维的脑啡肽样免疫反应性。
Proc Natl Acad Sci U S A. 1981 Feb;78(2):1255-9. doi: 10.1073/pnas.78.2.1255.

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Opposing expression gradients of calcitonin-related polypeptide alpha (Calca/Cgrpα) and tyrosine hydroxylase (Th) in type II afferent neurons of the mouse cochlea.
小鼠耳蜗II型传入神经元中降钙素相关多肽α(Calca/Cgrpα)和酪氨酸羟化酶(Th)的反向表达梯度。
J Comp Neurol. 2018 Feb 15;526(3):425-438. doi: 10.1002/cne.24341. Epub 2017 Nov 13.
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The efferent system or olivocochlear function bundle - fine regulator and protector of hearing perception.传出系统或橄榄耳蜗功能束——听觉感知的精细调节器和保护者。
Int J Biomed Sci. 2010 Dec;6(4):276-88.
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Olivocochlear innervation in the mouse: immunocytochemical maps, crossed versus uncrossed contributions, and transmitter colocalization.小鼠的橄榄耳蜗神经支配:免疫细胞化学图谱、交叉与非交叉贡献以及递质共定位
J Comp Neurol. 2003 Jan 13;455(3):406-16. doi: 10.1002/cne.10490.
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