大鼠柯蒂氏器中降钙素基因相关肽的个体发生
Ontogeny of calcitonin gene-related peptide in the organ of Corti of the rat.
作者信息
Tohyama Y, Kiyama H, Kitajiri M, Yamashita T, Kumazawa T, Tohyama M
机构信息
Department of Otolaryngology, Kansai Medical University, Japan.
出版信息
Brain Res Dev Brain Res. 1989 Feb 1;45(2):309-12. doi: 10.1016/0165-3806(89)90050-3.
The ontogeny of calcitonin gene-related peptide (CGRP)-like immunoreactive (CGRPI) fibers in the rat cochlea was examined using immunocytochemistry. It was found that the CGRPI cochlear system developed markedly in the postnatal period; CGRPI fibers first appeared in the inner spiral bundle at postnatal day 8, then at the base of the outer hair cells, tunnel spiral bundle and tunnel radial fibers at postnatal day 19. The ontogenetical profile elucidated by this study suggests that CGRP has a role as a neuromodulator or neurotransmitter in this system.
利用免疫细胞化学方法研究了大鼠耳蜗中降钙素基因相关肽（CGRP）样免疫反应性（CGRPI）纤维的个体发生。结果发现，CGRPI耳蜗系统在出生后显著发育；CGRPI纤维在出生后第8天首次出现在内螺旋束，然后在出生后第19天出现在外毛细胞基部、隧道螺旋束和隧道放射状纤维。本研究阐明的个体发生情况表明，CGRP在该系统中作为神经调节剂或神经递质发挥作用。
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