Department of Cardiology, Chinese People's Liberation Army General Hospital, Medical School of Chinese PLA, 28 Fuxing Road, Haidian District, Beijing, China.
Rheumatology Department, Kailuan General Hospital, 57 Xinhua East Road, Tangshan, 063020, Hebei, China.
Clin Res Cardiol. 2021 Jul;110(7):1096-1105. doi: 10.1007/s00392-021-01849-4. Epub 2021 Apr 12.
Hyperuricemia is associated with cardiovascular mortality, but the association of the age at hyperuricemia onset with cardiovascular disease (CVD) and mortality is still unclear.
The purpose of this study was to examine the associations of hyperuricemia onset age with CVD and all-cause mortality.
A total of 82,219 participants free of hyperuricemia and CVD from 2006 to 2015 in the Kailuan study were included. The analysis cohort comprised 18,311 new-onset hyperuricemia patients and controls matched for age and sex from the general population. Adjusted associations were estimated using Cox models for CVD and all-cause mortality across a range of ages.
There were 1,021 incident cases of CVD (including 215 myocardial infarctions, 814 strokes) and 1459 deaths during an average of 5.2 years of follow-up. Patients with hyperuricemia onset at an age < 45 years had the highest hazard ratios (HRs) (1.78 (1.14-2.78) for CVD and 1.64 (1.04-2.61) for all-cause mortality relative to controls). The HRs of CVD and all-cause mortality were 1.32 (1.05-1.65) and 1.40 (1.08-1.81) for the 45-54 years age group, 1.23 (0.97-1.56) and 1.37 (1.11 to 1.72) for the 55-64 years age group, and 1.10 (0.88-1.39) and 0.88 (0.76-1.01) for the ≥ 65 years age group, respectively.
The age at hyperuricemia onset was identified as an important predictor of CVD and all-cause mortality risk, and the prediction was more powerful in those with a younger age of hyperuricemia onset. Early onset of hyperuricemia is associated with increased cardiovascular disease and mortality risk.
高尿酸血症与心血管死亡率相关，但高尿酸血症发病年龄与心血管疾病（CVD）和死亡率的关系尚不清楚。
本研究旨在探讨高尿酸血症发病年龄与 CVD 和全因死亡率的关系。
共纳入 2006 年至 2015 年来自开滦研究的 82219 例无高尿酸血症和 CVD 的参与者。分析队列包括来自普通人群的 18311 例新发高尿酸血症患者和年龄及性别匹配的对照。使用 Cox 模型估计 CVD 和全因死亡率在不同年龄段的调整关联。
在平均 5.2 年的随访期间，共发生 1021 例 CVD（包括 215 例心肌梗死和 814 例卒中）和 1459 例死亡。与对照组相比，发病年龄<45 岁的高尿酸血症患者发生 CVD（1.78 [1.14-2.78]）和全因死亡率（1.64 [1.04-2.61]）的风险最高。45-54 岁年龄组的 CVD 和全因死亡率的 HR 分别为 1.32（1.05-1.65）和 1.40（1.08-1.81），55-64 岁年龄组的 HR 分别为 1.23（0.97-1.56）和 1.37（1.11-1.72），≥65 岁年龄组的 HR 分别为 1.10（0.88-1.39）和 0.88（0.76-1.01）。
高尿酸血症发病年龄是 CVD 和全因死亡率风险的重要预测因素，发病年龄越早，预测作用越强。高尿酸血症的早发与心血管疾病和死亡率风险增加有关。
