Yu Xi, Przybelski Scott A, Reid Robert I, Lesnick Timothy G, Raghavan Sheelakumari, Graff-Radford Jonathan, Lowe Val J, Kantarci Kejal, Knopman David S, Petersen Ronald C, Jack Clifford R, Vemuri Prashanthi
Department of Physiology and Biomedical Engineering Mayo Clinic Rochester Minnesota USA.
Department of Health Sciences Research Division of Biomedical Statistics and Informatics Mayo Clinic-Rochester Rochester Minnesota USA.
Alzheimers Dement (Amst). 2024 Jul 29;16(3):e12627. doi: 10.1002/dad2.12627. eCollection 2024 Jul-Sep.
Age-related and Alzheimer's disease (AD) dementia-related neurodegeneration impact brain health. While morphometric measures from T1-weighted scans are established biomarkers, they may be less sensitive to earlier changes. Neurite orientation dispersion and density imaging (NODDI), offering biologically meaningful interpretation of tissue microstructure, may be an advanced brain health biomarker.
We contrasted regional gray matter NODDI and morphometric evaluations concerning their correlation with (1) age, (2) clinical diagnosis stage, and (3) tau pathology as assessed by AV1451 positron emission tomography.
Our study hypothesizes that NODDI measures are more sensitive to aging and early AD changes than morphometric measures. One NODDI output, free water fraction (FWF), showed higher sensitivity to age-related changes, generally better effect sizes in separating mild cognitively impaired from cognitively unimpaired participants, and stronger associations with regional tau deposition than morphometric measures.
These findings underscore NODDI's utility in capturing early neurodegenerative changes and enhancing our understanding of aging and AD.
Neurite orientation dispersion and density imaging can serve as an effective brain health biomarker for aging and early Alzheimer's disease (AD).Free water fraction has higher sensitivity to normal brain aging.Free water fraction has stronger associations with early AD and regional tau deposition.
与年龄相关的和阿尔茨海默病（AD）痴呆相关的神经退行性变会影响大脑健康。虽然来自T1加权扫描的形态测量指标是已确立的生物标志物，但它们可能对早期变化不太敏感。神经突方向离散度和密度成像（NODDI）能够对组织微观结构进行具有生物学意义的解释，可能是一种先进的大脑健康生物标志物。
我们对比了区域灰质NODDI和形态测量评估与以下方面的相关性：（1）年龄，（2）临床诊断阶段，以及（3）通过AV1451正电子发射断层扫描评估的tau病理。
我们的研究假设，NODDI测量指标比形态测量指标对衰老和早期AD变化更敏感。NODDI的一个输出指标，即自由水分数（FWF），对与年龄相关的变化表现出更高的敏感性，在区分轻度认知障碍和认知未受损参与者方面通常具有更好的效应量，并且与区域tau沉积的关联比形态测量指标更强。
这些发现强调了NODDI在捕捉早期神经退行性变化以及增进我们对衰老和AD的理解方面的效用。
神经突方向离散度和密度成像可作为衰老和早期阿尔茨海默病（AD）的一种有效的大脑健康生物标志物。自由水分数对正常脑衰老具有更高的敏感性。自由水分数与早期AD及区域tau沉积的关联更强。
