Pillai Jay J, Reid Robert I, Weigand Stephen D, Cogswell Petrice M, Vemuri Prashanthi, Machulda Mary M, Knopman David S, Graff-Radford Jonathan, Petersen Ronald C, Jack Clifford R
Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Department of Information Technology, Mayo Clinic, Rochester, Minnesota, USA.
Alzheimers Dement. 2025 Jun;21(6):e70384. doi: 10.1002/alz.70384.
Temporal cortical microstructural changes precede cortical atrophy during memory decline. We used neurite orientation dispersion and density imaging (NODDI) to assess such early microstructural change.
Cognitively unimpaired (CU, n = 725) and mildly cognitively impaired (MCI, n = 111) participants from the Mayo Clinic Study of Aging underwent 3T magnetic resonance imaging (MRI), including NODDI and neuropsychological evaluation for calculation of memory z scores. Linear mixed effects modelling assessed the relationship between temporal cortical Neurite Density Index (NDI), Orientation Dispersion Index (ODI), and both baseline and mean annual change in memory z scores.
NDI was significantly associated with both baseline memory z scores and mean annual change of memory z scores, in the hippocampi and amygdalae. Similar significant associations with ODI were seen in hippocampi, parahippocampal, and fusiform gyri.
Temporal cortical NDI and ODI are early imaging biomarkers of cortical microstructural integrity that may predict memory decline in CU and MCI individuals.
We imaged 836 participants in the Mayo Clinic Study of Aging, who were either cognitively unimpaired (CU) or suffered from mild cognitive impairment (MCI). Neurite orientation dispersion and density imaging (NODDI) is an advanced diffusion magnetic resonance imaging (MRI) technique We found significant associations between new NODDI imaging biomarkers of microstructural integrity and memory function in CU and MCI individuals These relationships were both cross-sectional in nature and associated with future memory decline Future application of NODDI imaging biomarkers in the setting of anti-amyloid monoclonal antibody therapy may provide greater insight into memory decline than current cortical atrophy measures.
在记忆衰退过程中，颞叶皮质微结构变化先于皮质萎缩出现。我们使用神经突方向离散度与密度成像（NODDI）来评估这种早期微结构变化。
来自梅奥诊所衰老研究的认知未受损（CU，n = 725）和轻度认知受损（MCI，n = 111）参与者接受了3T磁共振成像（MRI）检查，包括NODDI和神经心理学评估，以计算记忆z分数。线性混合效应模型评估了颞叶皮质神经突密度指数（NDI）、方向离散度指数（ODI）与记忆z分数的基线值和年平均变化之间的关系。
在海马体和杏仁核中，NDI与记忆z分数的基线值和年平均变化均显著相关。在海马体、海马旁回和梭状回中，ODI也有类似的显著相关性。
颞叶皮质NDI和ODI是皮质微结构完整性的早期成像生物标志物，可能预测CU和MCI个体的记忆衰退。
我们对梅奥诊所衰老研究中的836名参与者进行了成像，他们要么认知未受损（CU），要么患有轻度认知障碍（MCI）。神经突方向离散度与密度成像（NODDI）是一种先进的扩散磁共振成像（MRI）技术。我们发现，新的NODDI成像生物标志物与CU和MCI个体的微结构完整性和记忆功能之间存在显著关联。这些关系本质上都是横断面的，并且与未来记忆衰退相关。NODDI成像生物标志物在抗淀粉样单克隆抗体治疗中的未来应用可能比目前的皮质萎缩测量方法能更深入地了解记忆衰退。
