Klotho: A Large Protein with Various Beneficial Functions, but also with Therapeutic Value?
作者信息
Yanucil Christopher, Faul Christian
机构信息
Alpha Young LLC, Carlsbad, California.
Division of Nephrology and Section of Mineral Metabolism, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama.
出版信息
J Am Soc Nephrol. 2024 Apr 26;35(9):1270-3. doi: 10.1681/ASN.0000000000000388.
Abstract
摘要
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本文引用的文献
1
Fibroblast growth factor 23, klotho and heparin.成纤维细胞生长因子 23、klotho 和肝素。
Curr Opin Nephrol Hypertens. 2023 Jul 1;32(4):313-323. doi: 10.1097/MNH.0000000000000895. Epub 2023 May 4.
2
Soluble α-klotho and heparin modulate the pathologic cardiac actions of fibroblast growth factor 23 in chronic kidney disease.可溶性 α-klotho 和肝素调节慢性肾脏病中成纤维细胞生长因子 23 的病理性心脏作用。
Kidney Int. 2022 Aug;102(2):261-279. doi: 10.1016/j.kint.2022.03.028. Epub 2022 May 2.
3
Klotho in Clinical Nephrology: Diagnostic and Therapeutic Implications.Klotho 在临床肾脏病学中的作用：诊断和治疗意义。
Clin J Am Soc Nephrol. 2020 Dec 31;16(1):162-176. doi: 10.2215/CJN.02840320. Epub 2020 Jul 22.
4
Structure-function relationships of the soluble form of the antiaging protein Klotho have therapeutic implications for managing kidney disease.Klotho 这种抗衰老蛋白的可溶性形式的结构-功能关系对管理肾脏疾病具有治疗意义。
J Biol Chem. 2020 Mar 6;295(10):3115-3133. doi: 10.1074/jbc.RA119.012144. Epub 2020 Jan 31.
5
FGF23 expression is stimulated in transgenic α-Klotho longevity mouse model.成纤维细胞生长因子 23 的表达在转基因 α-Klotho 长寿小鼠模型中受到刺激。
JCI Insight. 2019 Dec 5;4(23):132820. doi: 10.1172/jci.insight.132820.
6
FGF23 Actions on Target Tissues-With and Without Klotho.成纤维细胞生长因子23对靶组织的作用——有和没有α-klotho的情况。
Front Endocrinol (Lausanne). 2018 May 2;9:189. doi: 10.3389/fendo.2018.00189. eCollection 2018.
7
α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling.α-klotho 是 FGF23 激素信号的非酶分子支架。
Nature. 2018 Jan 25;553(7689):461-466. doi: 10.1038/nature25451. Epub 2018 Jan 17.
8
Recombinant α-Klotho may be prophylactic and therapeutic for acute to chronic kidney disease progression and uremic cardiomyopathy.重组α-klotho可能对急性至慢性肾病进展和尿毒症性心肌病具有预防和治疗作用。
Kidney Int. 2017 May;91(5):1104-1114. doi: 10.1016/j.kint.2016.10.034. Epub 2017 Jan 25.
9
Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy.心脏成纤维细胞生长因子受体4的激活导致左心室肥厚。
Cell Metab. 2015 Dec 1;22(6):1020-32. doi: 10.1016/j.cmet.2015.09.002. Epub 2015 Oct 1.
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Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule.Klotho：一种新型的磷质排泄物质，在肾近端小管中作为自分泌酶发挥作用。
FASEB J. 2010 Sep;24(9):3438-50. doi: 10.1096/fj.10-154765. Epub 2010 May 13.
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