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8例在莫桑比克感染的耐氯喹恶性疟病例

[8 cases of drug-resistant Plasmodium falciparum malaria contracted in Mozambique].

作者信息

Charmot G, Le Bras J, Sansonetti P, Dupont B, Lapresle C

出版信息

Bull Soc Pathol Exot Filiales. 1985;78(4):500-4.

PMID:3907877
Abstract

Between April and June 1984, eight chloroquine-resistant P. falciparum malaria cases were observed in non-immune patients after their emergency sanitary return from NE Mozambique. In vivo resistance to amodiaquine and pyrimethamine were demonstrated from two isolates. Radical cure was obtained with mefloquine in all cases. These patients came from an expatriate community of 35 adult men among which six other chloroquine-resistant malarial cases were probable. The epidemic pattern of this chloroquine-resistant focus is underlined.

摘要

1984年4月至6月期间,在8名非免疫患者从莫桑比克东北部紧急卫生遣返后,观察到8例对氯喹耐药的恶性疟原虫疟疾病例。从两个分离株中证实了对阿莫地喹和乙胺嘧啶的体内耐药性。所有病例均使用甲氟喹获得了根治。这些患者来自一个由35名成年男性组成的侨民社区,其中可能还有另外6例对氯喹耐药的疟疾病例。强调了这种对氯喹耐药疫源地的流行模式。

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