两名重症联合免疫缺陷患者在移植胎儿胸腺和肝脏或单倍体相同的经大豆凝集素处理的骨髓细胞后，HNK-1+细胞的自然杀伤活性缺乏。
Deficiency of NK activity of HNK-1+ cells after transplantation of fetal thymus and liver or haploidentical soybean agglutinin-treated marrow cells in two severe combined immunodeficiency patients.
作者信息
Gotoh Y I, Yamaguchi Y, Minegishi M, Konno T, Tada K
出版信息
Clin Exp Immunol. 1985 Sep;61(3):608-13.
Abstract
Two severe combined-immunodeficiency patients successfully transplanted with fetal thymus and liver or haploidentical lectin-treated marrow cells lacked NK activity, with a normal number of HNK1+ cell-defined NK cells. The defect was not due to the inhibiting factor in patients' sera. Their NK cells bound to their targets, but did not lyse them in a single-cell agarose assay, and did not respond to alpha-IFN or IL-2. IL-2 did not stimulated the development of mature NK cells that bear M1 antigens from precursors that lack M1 antigens.
摘要
两名严重联合免疫缺陷患者成功移植了胎儿胸腺和肝脏或单倍体相同的凝集素处理的骨髓细胞，缺乏自然杀伤（NK）活性，但具有正常数量的由HNK1 +细胞定义的NK细胞。该缺陷并非由于患者血清中的抑制因子所致。他们的NK细胞与靶细胞结合，但在单细胞琼脂糖试验中不裂解靶细胞，并且对α-干扰素或白细胞介素-2无反应。白细胞介素-2不能刺激缺乏M1抗原的前体发育成带有M1抗原的成熟NK细胞。
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Deficiency of NK activity of HNK-1+ cells after transplantation of fetal thymus and liver or haploidentical soybean agglutinin-treated marrow cells in two severe combined immunodeficiency patients.两名重症联合免疫缺陷患者在移植胎儿胸腺和肝脏或单倍体相同的经大豆凝集素处理的骨髓细胞后，HNK-1+细胞的自然杀伤活性缺乏。
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