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1
Deficiency of NK activity of HNK-1+ cells after transplantation of fetal thymus and liver or haploidentical soybean agglutinin-treated marrow cells in two severe combined immunodeficiency patients.两名重症联合免疫缺陷患者在移植胎儿胸腺和肝脏或单倍体相同的经大豆凝集素处理的骨髓细胞后，HNK-1+细胞的自然杀伤活性缺乏。
Clin Exp Immunol. 1985 Sep;61(3):608-13.
2
Evidence that appearance of thymulin in plasma follows lymphoid chimerism and precedes development of immunity in patients with lethal combined immunodeficiency transplanted with T cell-depleted haploidentical marrow.在接受去除T细胞的单倍体相合骨髓移植的重症联合免疫缺陷患者中，血浆中胸腺素的出现先于淋巴细胞嵌合体且早于免疫发展的证据。
Transplantation. 1990 Jul;50(1):55-61.
3
Phenotype and functional characterization of NK and LAK cells following T-depleted bone marrow transplantation.
Prog Clin Biol Res. 1987;244:423-32.
4
Successful lectin-separated bone marrow transplantation in adenosine deaminase deficiency-related severe immunodeficiency.腺苷脱氨酶缺乏相关严重免疫缺陷中成功的凝集素分离骨髓移植。
Haematologica. 1990 Nov-Dec;75(6):546-50.
5
Phenotypic and functional characterization of peripheral blood and bone marrow natural killer cells prior to autologous transplantation.自体移植前外周血和骨髓自然杀伤细胞的表型及功能特征
Bone Marrow Transplant. 1996 Mar;17(3):315-22.
6
NK cell function in severe combined immunodeficiency (SCID): evidence of a common T and NK cell defect in some but not all SCID patients.严重联合免疫缺陷（SCID）中的自然杀伤（NK）细胞功能：部分而非全部SCID患者存在常见T细胞和NK细胞缺陷的证据。
J Immunol. 1983 Nov;131(5):2332-9.
7
[Treatment of severe combined immunodeficiency with bone marrow or foetal liver transplants (author's transl)].用骨髓或胎肝移植治疗严重联合免疫缺陷（作者译）
Nouv Presse Med. 1980 Sep 13;9(32):2215-9.
8
Problems of mismatched bone marrow transplantation for severe combined immunodeficiency after soybean lectin fractionation.大豆凝集素分级分离后严重联合免疫缺陷的不匹配骨髓移植问题。
Birth Defects Orig Artic Ser. 1983;19(3):147-50.
9
Origin and differentiation of natural killer cells. I. Characteristics of a transplantable NK cell precursor.自然杀伤细胞的起源与分化。I. 可移植性自然杀伤细胞前体的特征
J Immunol. 1985 Jun;134(6):3731-8.
10
The development of NK cell activity in thymectomized bone marrow chimaeras.胸腺切除的骨髓嵌合体中自然杀伤细胞活性的发展
Immunology. 1984 Sep;53(1):17-22.

本文引用的文献

1
Deficiency of monoclonal antibody-defined NK Cells (HNK-1+) in primary immunodeficiency disorders.原发性免疫缺陷病中单抗定义的自然杀伤细胞（HNK-1+）缺乏。
Immunol Lett. 1982;5(6):327-9. doi: 10.1016/0165-2478(82)90122-5.
2
Reversal of natural killer defect in a patient with Chédiak-Higashi syndrome after bone-marrow transplantation.骨髓移植后一名患有切-东综合征患者自然杀伤细胞缺陷的逆转
N Engl J Med. 1982 Apr 29;306(17):1055-6. doi: 10.1056/nejm198204293061718.
3
Removal of PHA from supernatants containing T-cell growth factor.从含有T细胞生长因子的上清液中去除PHA。
J Immunol Methods. 1981;40(3):289-96. doi: 10.1016/0022-1759(81)90360-4.
4
Differentiation stages of human natural killer cells in lymphoid tissues from fetal to adult life.从胎儿期到成年期，人类自然杀伤细胞在淋巴组织中的分化阶段。
J Exp Med. 1983 Jan 1;157(1):273-84. doi: 10.1084/jem.157.1.273.
5
Interleukin 2 enhances natural killing of normal lymphocytes.白细胞介素2增强正常淋巴细胞的自然杀伤作用。
Cell Immunol. 1984 Mar;84(1):154-62. doi: 10.1016/0008-8749(84)90086-8.
6
NK cell function in severe combined immunodeficiency (SCID): evidence of a common T and NK cell defect in some but not all SCID patients.严重联合免疫缺陷（SCID）中的自然杀伤（NK）细胞功能：部分而非全部SCID患者存在常见T细胞和NK细胞缺陷的证据。
J Immunol. 1983 Nov;131(5):2332-9.
7
T cell growth factor from human splenic cell cultures: conditions for its production, and its utilization for maintenance of cytotoxic T cell lines.来自人脾细胞培养物的T细胞生长因子：其产生条件及其在维持细胞毒性T细胞系中的应用。
Microbiol Immunol. 1981;25(10):1077-86. doi: 10.1111/j.1348-0421.1981.tb00114.x.
8
Transplantation for severe combined immunodeficiency with HLA-A,B,D,DR incompatible parental marrow cells fractionated by soybean agglutinin and sheep red blood cells.采用大豆凝集素和绵羊红细胞对与 HLA - A、B、D、DR 不相容的亲代骨髓细胞进行分离后，用于重症联合免疫缺陷的移植。
Blood. 1983 Feb;61(2):341-8.
9
Rationale for combined use of fetal liver and thymus for immunological reconstitution in patients with variants of severe combined immunodeficiency.在重症联合免疫缺陷变异型患者中联合使用胎儿肝脏和胸腺进行免疫重建的理论依据。
Proc Natl Acad Sci U S A. 1977 Jul;74(7):3002-5. doi: 10.1073/pnas.74.7.3002.
10
Mechanism of cell-mediated cytotoxicity at the single cell level. I. Estimation of cytotoxic T lymphocyte frequency and relative lytic efficiency.单细胞水平的细胞介导细胞毒性机制。I. 细胞毒性T淋巴细胞频率及相对裂解效率的评估。
J Immunol. 1979 Dec;123(6):2861-9.

两名重症联合免疫缺陷患者在移植胎儿胸腺和肝脏或单倍体相同的经大豆凝集素处理的骨髓细胞后，HNK-1+细胞的自然杀伤活性缺乏。

Deficiency of NK activity of HNK-1+ cells after transplantation of fetal thymus and liver or haploidentical soybean agglutinin-treated marrow cells in two severe combined immunodeficiency patients.

作者信息

Gotoh Y I, Yamaguchi Y, Minegishi M, Konno T, Tada K

出版信息

Clin Exp Immunol. 1985 Sep;61(3):608-13.

PMID:3907904
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1577262/
Abstract

Two severe combined-immunodeficiency patients successfully transplanted with fetal thymus and liver or haploidentical lectin-treated marrow cells lacked NK activity, with a normal number of HNK1+ cell-defined NK cells. The defect was not due to the inhibiting factor in patients' sera. Their NK cells bound to their targets, but did not lyse them in a single-cell agarose assay, and did not respond to alpha-IFN or IL-2. IL-2 did not stimulated the development of mature NK cells that bear M1 antigens from precursors that lack M1 antigens.

摘要

两名严重联合免疫缺陷患者成功移植了胎儿胸腺和肝脏或单倍体相同的凝集素处理的骨髓细胞，缺乏自然杀伤（NK）活性，但具有正常数量的由HNK1 +细胞定义的NK细胞。该缺陷并非由于患者血清中的抑制因子所致。他们的NK细胞与靶细胞结合，但在单细胞琼脂糖试验中不裂解靶细胞，并且对α-干扰素或白细胞介素-2无反应。白细胞介素-2不能刺激缺乏M1抗原的前体发育成带有M1抗原的成熟NK细胞。