胸腺切除的骨髓嵌合体中自然杀伤细胞活性的发展
The development of NK cell activity in thymectomized bone marrow chimaeras.
作者信息
Sihvola M, Hurme M
出版信息
Immunology. 1984 Sep;53(1):17-22.
Most of the natural killer (NK) cells, recently derived from the bone marrow (14 days after injection of bone marrow cells into lethally irradiated mice), express the Thy-1 antigen; after some period of time (by day 28) a normal proportion (50%) of Thy-1+ NK cells is found. This study demonstrates that the shift of these Thy-1+ NK cells to Thy-1- NK cells is influenced by the thymus: NK cells developing in the total absence of the thymus--bone marrow (bm) cells from adult thymectomized (Tx) or nude (nu) mice injected into thymectomized recipients, (Tx) bm----(Tx) or nu bm----(Tx)--remain Thy-1+, while the presence of the thymus at some stage of the NK cell maturation--bone marrow cells injected into thymectomized recipients, bm----(Tx), or normal recipients reconstituted with bone marrow cells from thymectomized or nude mice, (Tx) bm----or nu bm----normal recipients--is sufficient for the development of normal ratio of Thy-1+ and Thy-1- NK cells.
大多数自然杀伤（NK）细胞，最近源自骨髓（将骨髓细胞注射到受致死剂量照射的小鼠体内14天后），表达Thy-1抗原；一段时间后（到第28天），发现Thy-1+ NK细胞的比例正常（50%）。本研究表明，这些Thy-1+ NK细胞向Thy-1- NK细胞的转变受胸腺影响：在完全没有胸腺的情况下发育的NK细胞——将成年胸腺切除（Tx）或裸鼠（nu）的骨髓（bm）细胞注射到胸腺切除的受体中，（Tx）bm----（Tx）或nu bm----（Tx）——仍为Thy-1+，而在NK细胞成熟的某个阶段存在胸腺——将骨髓细胞注射到胸腺切除的受体中，bm----（Tx），或用胸腺切除或裸鼠的骨髓细胞重建的正常受体，（Tx）bm----或nu bm----正常受体——足以使Thy-1+和Thy-1- NK细胞发育成正常比例。
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