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建立机构肝移植登记系统:机遇与挑战。

The building of an institutional liver transplant registry: opportunities and challenges.

机构信息

Hospital Italiano de Buenos Aires, Liver Unit, Buenos Aires, Argentina.

Hospital Italiano de Buenos Aires, Research Department, Buenos Aires, Argentina.

出版信息

J Int Med Res. 2024 Jul;52(7):3000605241264232. doi: 10.1177/03000605241264232.

DOI:10.1177/03000605241264232
PMID:39079129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11295234/
Abstract

To improve current data systems for institutional decision-making, the Adult Liver Transplant Registry was established at the Hospital Italiano de Buenos Aires, Argentina. This article describes its design and implementation and reports on the outcomes for patients transplanted since its January 2020 launch. A multidisciplinary team designed the registry by identifying key variables from a literature review while considering balance between data depth and feasibility. Rigorous quality control measures were enforced, including monthly audits and staff training. Benchmark indicators for post-transplant outcomes were established. As of November 2023, the registry included 136 transplants. Its implementation and maintenance were straightforward, with no significant difficulties encountered. Cirrhosis was the predominant indication (77%) for transplant. Only one living donor transplantation was performed. Post-transplant results generally aligned with benchmarks, but rates of biliary complications slightly exceeded the recommended thresholds. The one-year post-transplant survival rate was 87%. The successful registry implementation provides a robust framework for research, treatment management, and patient care enhancement within a liver transplant unit.

摘要

为了改善机构决策的现有数据系统,阿根廷布宜诺斯艾利斯意大利医院成立了成人肝移植登记处。本文描述了其设计和实施情况,并报告了自 2020 年 1 月推出以来接受移植的患者的结果。一个多学科团队通过从文献综述中确定关键变量来设计该登记处,同时考虑数据深度和可行性之间的平衡。实施了严格的质量控制措施,包括每月审核和员工培训。建立了移植后结果的基准指标。截至 2023 年 11 月,该登记处包括 136 例移植。其实施和维护简单,没有遇到重大困难。移植的主要适应症是肝硬化(77%)。仅进行了一次活体供者移植。移植后的结果通常与基准一致,但胆道并发症的发生率略高于推荐的阈值。移植后一年的生存率为 87%。成功实施登记处为肝移植单位的研究、治疗管理和患者护理提供了一个强大的框架。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cccc/11295234/78d9f6c594c3/10.1177_03000605241264232-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cccc/11295234/37b0f59b19be/10.1177_03000605241264232-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cccc/11295234/f4e53effdf7e/10.1177_03000605241264232-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cccc/11295234/d40e2cc63f21/10.1177_03000605241264232-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cccc/11295234/78d9f6c594c3/10.1177_03000605241264232-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cccc/11295234/37b0f59b19be/10.1177_03000605241264232-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cccc/11295234/f4e53effdf7e/10.1177_03000605241264232-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cccc/11295234/d40e2cc63f21/10.1177_03000605241264232-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cccc/11295234/78d9f6c594c3/10.1177_03000605241264232-fig4.jpg

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本文引用的文献

1
Liver Transplantation.肝移植
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2
Liver transplantation in adults with acute liver failure: Outcomes from the Argentinean Transplant Registry.成人急性肝衰竭肝移植:来自阿根廷移植登记处的结果。
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智利使用 MELD 评分进行肝移植的优先排序:MELD 例外产生的不公平:智利肝移植计划、公共卫生研究所和国家移植协调员之间的合作。
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Characteristics of Liver Transplantation in Argentina: A Multicenter Study.阿根廷肝移植的特点:一项多中心研究
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6
Defining Benchmarks in Liver Transplantation: A Multicenter Outcome Analysis Determining Best Achievable Results.定义肝移植的基准:一项多中心结局分析确定最佳可实现结果。
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Improved waiting-list outcomes in Argentina after the adoption of a model for end-stage liver disease-based liver allocation policy.阿根廷采用终末期肝病模型为基础的肝脏分配政策后,等待名单结果得到改善。
Liver Transpl. 2013 Jul;19(7):711-20. doi: 10.1002/lt.23665.
8
Evolution of indications and results of liver transplantation in Europe. A report from the European Liver Transplant Registry (ELTR).欧洲肝移植的适应证演变与结果。欧洲肝移植登记处(ELTR)的报告。
J Hepatol. 2012 Sep;57(3):675-88. doi: 10.1016/j.jhep.2012.04.015. Epub 2012 May 16.
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Liver transplantation for autoimmune hepatitis in Peru: outcomes and recurrence.秘鲁自身免疫性肝炎的肝移植:结局和复发。
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Recurrent and de novo autoimmune liver diseases.复发性和新发自身免疫性肝病。
Clin Liver Dis. 2011 Nov;15(4):859-78. doi: 10.1016/j.cld.2011.08.008. Epub 2011 Oct 1.