Department of Endocrinology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province 330000, China.
Department of General Surgery, The Third Hospital of Nanchang, Nanchang, Jiangxi Province 330000, China.
Prostaglandins Other Lipid Mediat. 2024 Oct;174:106877. doi: 10.1016/j.prostaglandins.2024.106877. Epub 2024 Jul 28.
There is controversial data on the impacts of bitter melon (Momordica charantia) supplementations on anthropometric indices. Thus, we aimed to clarify this role of bitter melon through a systematic review, and meta-analysis of the trials. All clinical trials conducted on the impact of bitter melon on anthropometric indices were published until August 2023 in PubMed, Web of Sciences, Scopus, Embase, and Cochrane Library web databases included. Overall, 10 studies with 448 individuals were included in the meta-analysis. Meta-analysis of 10 trials with 448 participants revealed no significant reductions in body weight (BW) (WMD: 0.04 Kg; 95 %CI: -0.16-0.25; P =0.651), body mass index (BMI) (WMD: -0.18 kg/m2; 95 %CI: -0.43-0.07; P =0.171), waist circumference (WC) (WMD: -0.95 cm; 95 % CI: -3.05-1.16; p =0.372), and percentage of body fat (PBF) (WMD: -0.99; 95 % CI: -2.33-0.35; p =0.141) following bitter melon supplementation. There was no significant impact of bitter melon supplementation on BW, BMI, WC, and PBF. More large-scale and high-quality RCTs are necessary to confirm these results.
关于苦瓜（Momordica charantia）补充剂对人体测量指数的影响，存在有争议的数据。因此，我们旨在通过系统评价和荟萃分析来阐明苦瓜的这一作用，该评价和荟萃分析纳入了截至 2023 年 8 月在 PubMed、Web of Sciences、Scopus、Embase 和 Cochrane Library 网络数据库中发表的所有关于苦瓜对人体测量指数影响的临床试验。总体而言，纳入的荟萃分析包括 10 项研究，共 448 人。对 10 项试验（共 448 名参与者）的荟萃分析显示，苦瓜补充剂并未显著降低体重（BW）（WMD：0.04 公斤；95%CI：-0.16-0.25；P=0.651）、体重指数（BMI）（WMD：-0.18 公斤/平方米；95%CI：-0.43-0.07；P=0.171）、腰围（WC）（WMD：-0.95 厘米；95%CI：-3.05-1.16；p=0.372）和体脂肪百分比（PBF）（WMD：-0.99；95%CI：-2.33-0.35；p=0.141）。苦瓜补充剂对 BW、BMI、WC 和 PBF 没有显著影响。需要更多大规模和高质量的 RCT 来证实这些结果。
