Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Phytomedicine. 2019 Oct;63:153018. doi: 10.1016/j.phymed.2019.153018. Epub 2019 Jul 5.
Given that the most recent systematic review investigating Green-Coffee Extract (GCE) as a weight loss facilitator was nearly a decade ago and that the authors reported there no consensus on the effect of GCE/CGA (Chlorogenic acids) on body composition indices, a comprehensive systematic review and dose-response meta-analysis of all available randomized controlled trial (RCTs) was undertaken to examine the effect of GCE and CGA intervention on body weight (BW), body mass index (BMI) and waist circumference (WC) in adults.
We conducted a systematic search of all available randomized controlled trials (RCTs) performed up to June 2019 in the following electronic databases: PubMed, Scopus and Google Scholar. RCTs that investigated the effect GCE/CGA Supplementation on BW, BMI and WC in adults were included for final analysis. The pooled weight mean difference (WMD) of included studies was estimated using a random-effects model.
A total of 13 articles with 16 RCTs were included in the meta-analysis. Results revealed significant reduction in BMI (WMD: -0.403 kg/m, 95% CI: -0.800, -0.005, p = 0.047) and no significant change in BW (WMD: -0.585 kg, 95% CI: -1.498, 0.329, p = 0.210) and WC (WMD: -0.847 cm, 95% CI: -1.764, 0.071, p = 0.070). In the subgroup analysis, studies that were conducted on baseline BMI ≥25 kg/m revealed a significant greater reduction in body weight and BMI than those performed on baseline BMI <25 kg/m. Moreover, short supplementation periods of less than 4 weeks had no effect.
The results of current meta-analysis study support the use of GCE supplementation for the improvement of obesity indices, with sub-group analysis highlighting greater improvements in individuals with a starting BMI ≥25 kg/m.
鉴于最近一次对绿咖啡提取物（GCE）作为减肥促进剂的系统评价是在近十年前进行的，而且作者报告称，对于 GCE/CGA（绿原酸）对身体成分指数的影响没有共识，因此进行了一项全面的系统评价和剂量反应荟萃分析，以检查 GCE 和 CGA 干预对成年人体重（BW）、体重指数（BMI）和腰围（WC）的影响。
我们对截至 2019 年 6 月在以下电子数据库中进行的所有可用随机对照试验（RCT）进行了系统搜索：PubMed、Scopus 和 Google Scholar。纳入最终分析的 RCT 研究了 GCE/CGA 补充剂对成年人 BW、BMI 和 WC 的影响。使用随机效应模型估计纳入研究的加权平均差异（WMD）。
共有 13 篇文章和 16 项 RCT 纳入荟萃分析。结果表明，BMI 显著降低（WMD：-0.403kg/m，95%CI：-0.800，-0.005，p=0.047），BW 无显著变化（WMD：-0.585kg，95%CI：-1.498，0.329，p=0.210）和 WC（WMD：-0.847cm，95%CI：-1.764，0.071，p=0.070）。在亚组分析中，对于基线 BMI≥25kg/m 的研究，体重和 BMI 的降低幅度明显大于基线 BMI<25kg/m 的研究。此外，持续时间不到 4 周的短期补充没有效果。
目前荟萃分析研究的结果支持使用 GCE 补充剂来改善肥胖指数，亚组分析强调在起始 BMI≥25kg/m 的个体中，改善效果更大。
