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Rhodium-Catalyzed Regioselective [4 + 2] Cycloaddition of Ynamines and 2-(Cyanomethyl)phenylboronates.

作者信息

Xie Zhong-Yang, Tang Conghui, Li Long, Zhou Zijun, Zou Jun, Qian Peng-Cheng

机构信息

College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325035, China.

Department of Chemistry, College of Sciences, Shanghai University, Shanghai 200444, China.

出版信息

Org Lett. 2024 Aug 9;26(31):6586-6590. doi: 10.1021/acs.orglett.4c02120. Epub 2024 Jul 30.

DOI:10.1021/acs.orglett.4c02120
PMID:39079756
Abstract

A rhodium-catalyzed [4 + 2] cycloaddition of ynamines and 2-(cyanomethyl)phenylboronates has been developed, leading to efficient and excellent regioselective synthesis of valuable indole-linked aromatic compounds in a concise and flexible approach. Interestingly, this strategy was successful in the construction of C···N axially chiral indoles with high enantiocontrol by the introduction of a new phosphoramidite ligand (Xie-Phos).

摘要

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