Coruzzi P, Biggi A, Musiari L, Ravanetti C, Novarini A
Eur J Clin Pharmacol. 1985;29(3):371-4. doi: 10.1007/BF00544096.
Cardiovascular, baroreflex and humoral responses were evaluated in 8 patients with essential hypertension during a control period and then after oral treatment for 5 days with nicardipine hydrochloride 60 mg/d, a calcium channel antagonist. Systolic, diastolic and mean arterial cuff pressures fell after the treatment from 145.7, 98.6 and 114 mmHg control to 136.5, 86.1 and 102.9 mmHg. Heart rate increased from 71 to 78.7 beats/min indicating activation of the baroreflex control mechanism. Neurally mediated changes in the cardiovascular responses to an increase in carotid baroceptor activity and to dynamic exercise were not affected by the drug, nor was the renin-aldosterone system. Thus, a clinically dose of nicardipine significantly reduced mean arterial pressure, whilst preserving circulatory homeostasis.
在8例原发性高血压患者的对照期以及口服盐酸尼卡地平60mg/d（一种钙通道拮抗剂）治疗5天后，对其心血管、压力反射和体液反应进行了评估。治疗后，收缩压、舒张压和平均动脉袖带压从对照期的145.7、98.6和114mmHg降至136.5、86.1和102.9mmHg。心率从71次/分钟增加到78.7次/分钟，表明压力反射控制机制被激活。药物对心血管系统对颈动脉压力感受器活动增加和动态运动的神经介导反应没有影响，对肾素-醛固酮系统也没有影响。因此，临床剂量的尼卡地平可显著降低平均动脉压，同时维持循环稳态。
