Kishi Y, Okumura F, Furuya H
Br J Anaesth. 1984 Sep;56(9):1003-7. doi: 10.1093/bja/56.9.1003.
Fourteen patients with vascular disease were studied to evaluate the efficacy of nicardipine hydrochloride as a hypotensive agent in the treatment of acute hypertension occurring during anaesthesia. Five patients received a bolus injection of nicardipine hydrochloride 0.5 mg. Another nine patients received bolus injections of nicardipine 1 and 2 mg. Nicardipine 0.5 mg significantly decreased systemic arterial pressure (by about 24%), systemic vascular resistance (SVR), left ventricular stroke work index (LVSWI) and rate-pressure product (RPP). Nicardipine 1 or 2 mg had twice the effect in decreasing arterial pressure as did 0.5 mg, without significant change in heart rate or right and left ventricular filling pressures. Cardiac index and stroke volume index increased and SVR, pulmonary vascular resistance, LVSWI and RPP decreased significantly.
对14例血管疾病患者进行了研究，以评估盐酸尼卡地平作为降压药在治疗麻醉期间发生的急性高血压中的疗效。5例患者接受了0.5mg盐酸尼卡地平的静脉推注。另外9例患者接受了1mg和2mg尼卡地平的静脉推注。0.5mg尼卡地平显著降低了体动脉压（约24%）、体循环血管阻力（SVR）、左心室每搏功指数（LVSWI）和心率血压乘积（RPP）。1mg或2mg尼卡地平降低动脉压的效果是0.5mg的两倍，心率以及左右心室充盈压无显著变化。心脏指数和每搏量指数增加，SVR、肺血管阻力、LVSWI和RPP显著降低。
