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取决于肥胖状况，[具体物质]对病毒感染后长期康复患者胰岛素抵抗和凝血的调节作用

Modulatory role of on insulin resistance and coagulation in patients with post-viral long haulers depending on adiposity.

作者信息

Cuevas-Sierra Amanda, Chero-Sandoval Lourdes, Higuera-Gómez Andrea, Vargas J Antonio, Martínez-Urbistondo María, Castejón Raquel, Martínez J Alfredo

机构信息

Precision Nutrition and Cardiometabolic Health, IMDEA-Food Institute (Madrid Institute for Advanced Studies), Campus of International Excellence (CEI) UAM+CSIC, 28049 Madrid, Spain.

Department of Endocrinology and Nutrition of the University Clinical Hospital, University of Valladolid, 47002 Valladolid, Spain.

出版信息

iScience. 2024 Jul 6;27(8):110450. doi: 10.1016/j.isci.2024.110450. eCollection 2024 Aug 16.

DOI:10.1016/j.isci.2024.110450
PMID:39081294
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11284562/
Abstract

Patients with Post-viral long hauler encompass lasting symptoms and comorbid complexities, often exacerbated in individuals with excessive body weight. The aim was to study gut microbiota in 130 patients with post-viral long hauler stratified by body mass index (BMI) and the relationship between inflammation and microbiota. Significant higher values were found for anthropometric variables and markers of glucose and dyslipidemia in individuals with higher BMI, as well as elevated levels of C-reactive protein, fibrinogen, IL-6, uric acid, and D-dimer. An interactive association showed an interplay between , D-dimer levels, and insulin resistance. This investigation showed that anthropometric, biochemical, and inflammatory variables were impaired in patients with post-viral long haulers with higher BMI. In addition, gut microbiota differences were found between groups and a modification effect on abundance regarding insulin resistance and D-dimer. These findings suggest that considering adiposity and gut microbiota structure and composition may improve personalized clinical interventions in patients with chronic inflammation.

摘要

病毒感染后长期症状患者存在持续症状和共病复杂性，超重个体的这些情况往往会加剧。目的是研究130例按体重指数（BMI）分层的病毒感染后长期症状患者的肠道微生物群，以及炎症与微生物群之间的关系。BMI较高的个体在人体测量变量以及血糖和血脂异常标志物方面的值显著更高，同时C反应蛋白、纤维蛋白原、白细胞介素-6、尿酸和D-二聚体水平也升高。一种交互关联显示了D-二聚体水平与胰岛素抵抗之间的相互作用。这项研究表明，BMI较高的病毒感染后长期症状患者的人体测量、生化和炎症变量受损。此外，在不同组之间发现了肠道微生物群差异，并且在胰岛素抵抗和D-二聚体方面对丰度有调节作用。这些发现表明，考虑肥胖以及肠道微生物群的结构和组成可能会改善对慢性炎症患者的个性化临床干预。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/250b/11284562/07d48b8a679c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/250b/11284562/56d35b5835dc/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/250b/11284562/4ec6ba64259e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/250b/11284562/1801526473b6/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/250b/11284562/d0e4cdda93c6/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/250b/11284562/07d48b8a679c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/250b/11284562/56d35b5835dc/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/250b/11284562/4ec6ba64259e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/250b/11284562/1801526473b6/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/250b/11284562/d0e4cdda93c6/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/250b/11284562/07d48b8a679c/gr4.jpg

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