Gorostowicz Aleksandra, Chrobak Adrian Andrzej, Dudek Dominika, Siwek Marcin
Uniwersytet Jagielloński Collegium Medicum, Katedra Psychiatrii.
Uniwersytet Jagielloński Collegium Medicum, Katedra Psychiatrii, Zakład Zaburzeń Afektywnych.
Psychiatr Pol. 2024 Jul 15:1-16. doi: 10.12740/PP/OnlineFirst/183418.
The purpose of this study was to examine relationship between anhedonia, disruption of biological rhythms, functioning and depression severity in patients with bipolar disorder (BD).
The sample included 58 patients with bipolar depression aged 18-65 years. The participants were assessed using the following scales: Dimensional Anhedonia Rating Scale (DARS), Snaith-Hamilton Pleasure Scale (SHAPS), Quick Inventory of Depressive Symptomatology- self-report (QIDS-SR), Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN), Functioning Assessment Short Test (FAST). Correlations between the variables were calculated. We built linear regression models with FAST or QIDS-SR as a dependent variable. Mediation analysis was performed.
Statistically significant correlations were observed between the included variables. Biological rhythms dysregulation and anhedonia were independent predictors of the level of functioning or depression severity. Mediation analysis demonstrated statistically significant mediation of the relationship between anhedonia and depression severity/functioning by the BRIAN score.
We demonstrated for the first time the interactions between anhedonia, dysregulation of biological rhythms and functioning/depression severity in patients with BD. Reward deficits by causing disruption of rhythm of daily activities and social contacts may result in more difficulties in functioning and higher intensity of depressive symptoms.
本研究旨在探讨双相情感障碍（BD）患者快感缺失、生物节律紊乱、功能状态与抑郁严重程度之间的关系。
样本包括58例年龄在18至65岁之间的双相抑郁患者。使用以下量表对参与者进行评估：维度快感缺失评定量表（DARS）、斯奈斯 - 汉密尔顿愉悦量表（SHAPS）、抑郁症状快速自评量表（QIDS - SR）、神经精神病学评估中的生物节律访谈（BRIAN）、功能评估简短测试（FAST）。计算变量之间的相关性。我们构建了以FAST或QIDS - SR为因变量的线性回归模型。进行中介分析。
在所纳入的变量之间观察到具有统计学意义的相关性。生物节律失调和快感缺失是功能水平或抑郁严重程度的独立预测因素。中介分析表明，BRIAN评分对快感缺失与抑郁严重程度/功能状态之间的关系具有统计学意义的中介作用。
我们首次证明了BD患者中快感缺失、生物节律失调与功能状态/抑郁严重程度之间的相互作用。奖赏缺乏通过导致日常活动节奏和社交接触的紊乱，可能导致更多的功能障碍和更高强度的抑郁症状。
