National Multiple Sclerosis Society, New York, NY, USA.
Multiple Sclerosis Society UK, London, UK.
Mult Scler. 2024 Sep;30(10):1363-1369. doi: 10.1177/13524585241265961. Epub 2024 Jul 31.
Multiple sclerosis (MS) is an immune-mediated central nervous system disorder and a growing global health challenge affecting nearly 3 million people worldwide. Incidence and prevalence continue to increase with no known cause or cure. Globally governments and non-profit organizations fund research toward better understanding of and treatments for multiple sclerosis.
This study identified MS research projects funded between 2021 and 2023 by government and non-profit organization sources. Projects were described by type of scientific approach, Pathways to Cure research category (i.e. Stop, Restore, End), and other key characteristics.
Over 2,300 MS research projects were identified through 16 non-profit MS organizations and 18 government databases. The overall global portfolio of these projects is valued at nearly one and a half billion Euros. The majority of projects were classified in the Stop category (60%). Research collaboration occurs in many forms among the research community; around 272 projects were reported to be co-funded.
Global MS research collaboration will accelerate progress toward increased knowledge, effective treatments, improved health outcomes, and ultimately cures for MS. This landscape analysis highlights the current distribution of MS research investment between topics and begins to suggest where the MS community should focus to increase potential impact for current and future endeavors.
多发性硬化症（MS）是一种免疫介导的中枢神经系统疾病，也是一个日益严重的全球性健康挑战，影响着全球近 300 万人。其发病率和患病率持续上升，但病因和治疗方法仍不清楚。全球各国政府和非营利组织都在资助研究，以更好地了解多发性硬化症并开发治疗方法。
本研究确定了 2021 年至 2023 年期间，由政府和非营利组织资助的多发性硬化症研究项目。项目按科学方法类型、“治愈途径”（停止、恢复、终结）研究类别以及其他关键特征进行描述。
通过 16 个非盈利性多发性硬化症组织和 18 个政府数据库，共确定了 2300 多个多发性硬化症研究项目。这些项目的全球总投资价值接近 15 亿欧元。大多数项目被归类为“停止”类别（60%）。研究界以多种形式进行合作；约有 272 个项目被报告为共同资助。
全球多发性硬化症研究合作将加速知识的增长、有效的治疗方法的开发、改善健康结果，并最终为多发性硬化症带来治愈方法。这项分析强调了当前多发性硬化症研究投资在不同主题之间的分布，并开始提示多发性硬化症社区应在何处集中精力，以增加当前和未来努力的潜在影响。
