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Single-nucleus RNA sequencing identifies cell-type-specific effects of sodium-glucose co-transporter 2 inhibitors in human myocardial slices.

作者信息

Schmidt Kevin, Fuchs Maximilian, Weber Natalie, Werlein Christopher, Schmitto Jan D, Ius Fabio, Ruhparwar Arjang, Bär Christian, Fiedler Jan, Thum Thomas

机构信息

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, Germany.

出版信息

Eur Heart J. 2024 Sep 14;45(35):3292-3295. doi: 10.1093/eurheartj/ehae472.

DOI:10.1093/eurheartj/ehae472
PMID:39082743
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11400937/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/add6/11400937/a265f2ef08fe/ehae472f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/add6/11400937/a265f2ef08fe/ehae472f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/add6/11400937/a265f2ef08fe/ehae472f1.jpg

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Hypertrophic cardiomyopathy dysfunction mimicked in human engineered heart tissue and improved by sodium-glucose cotransporter 2 inhibitors.肥厚型心肌病功能障碍在人源工程心脏组织中得到模拟,并通过钠-葡萄糖共转运蛋白 2 抑制剂得到改善。
Cardiovasc Res. 2024 Mar 14;120(3):301-317. doi: 10.1093/cvr/cvae004.
2
Dapagliflozin protects against chronic heart failure in mice by inhibiting macrophage-mediated inflammation, independent of SGLT2.达格列净通过抑制巨噬细胞介导体液炎症来预防小鼠慢性心力衰竭,与 SGLT2 无关。
Cell Rep Med. 2023 Dec 19;4(12):101334. doi: 10.1016/j.xcrm.2023.101334.
3
2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure.
Cardiovasc Res. 2025 May 23;121(5):730-747. doi: 10.1093/cvr/cvaf030.
《2021年欧洲心脏病学会急性和慢性心力衰竭诊断与治疗指南》2023年聚焦更新
Eur Heart J. 2023 Oct 1;44(37):3627-3639. doi: 10.1093/eurheartj/ehad195.
4
Implementation of sodium-glucose cotransporter 2 inhibitors for heart failure with reduced ejection fraction: Where we are versus where we need to be.钠-葡萄糖协同转运蛋白2抑制剂在射血分数降低的心力衰竭中的应用:我们所处的位置与我们需要达到的位置。
Eur J Heart Fail. 2023 Sep;25(9):1659-1662. doi: 10.1002/ejhf.2999. Epub 2023 Aug 22.
5
Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure.单细胞 RNA 测序在缺血性心肌病中揭示了终末期心力衰竭的常见转录谱。
Cell Rep. 2023 Feb 28;42(2):112086. doi: 10.1016/j.celrep.2023.112086. Epub 2023 Feb 14.
6
Critical Reanalysis of the Mechanisms Underlying the Cardiorenal Benefits of SGLT2 Inhibitors and Reaffirmation of the Nutrient Deprivation Signaling/Autophagy Hypothesis.对 SGLT2 抑制剂心脏肾脏获益机制的关键再分析及营养剥夺信号/自噬假说的再确认。
Circulation. 2022 Nov;146(18):1383-1405. doi: 10.1161/CIRCULATIONAHA.122.061732. Epub 2022 Oct 31.
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2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure.2021年欧洲心脏病学会急性和慢性心力衰竭诊断与治疗指南。
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